Mank Arenda, van Maurik Ingrid S, Rijnhart Judith J M, Rhodius-Meester Hanneke F M, Visser Leonie N C, Lemstra Afina W, Sikkes Sietske A M, Teunissen Charlotte E, van Giessen Elsmarieke M, Berkhof Johannes, van der Flier Wiesje M
Alzheimer Center Amsterdam, Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC VUmc Amsterdam the Netherlands.
Amsterdam Neuroscience Neurodegeneration Amsterdam the Netherlands.
Alzheimers Dement (Amst). 2023 Apr 25;15(2):e12418. doi: 10.1002/dad2.12418. eCollection 2023 Apr-Jun.
We evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages.
We included = 270 care partners of amyloid-positive patients in the pre-dementia and dementia stages of AD. Using linear regression analysis, we examined determinants of four care partner outcomes: informal care time, caregiver distress, depression, and quality of life (QoL).
More behavioral symptoms and functional impairment in patients were associated with more informal care time and depressive symptoms in care partners. More behavioral symptoms were related with more caregiver distress. Spouse care partners spent more time on informal care and QoL was lower in female care partners. Behavioral problems and subtle functional impairment of the patient predisposed for worse care partner outcomes already in the pre-dementia stages.
Both patient and care partner determinants contribute to the care partner outcomes, already in early disease stages. This study provides red flags for high care partner burden.
我们评估了阿尔茨海默病（AD）各阶段与照护伙伴结局相关的决定因素。
我们纳入了270名处于AD痴呆前和痴呆阶段的淀粉样蛋白阳性患者的照护伙伴。使用线性回归分析，我们研究了四个照护伙伴结局的决定因素：非正式照护时间、照料者困扰、抑郁和生活质量（QoL）。
患者更多的行为症状和功能损害与照护伙伴更多的非正式照护时间和抑郁症状相关。更多的行为症状与更多的照料者困扰有关。配偶照护伙伴花费更多时间进行非正式照护，女性照护伙伴的生活质量较低。患者的行为问题和轻微功能损害在痴呆前阶段就已预示着照护伙伴的结局更差。
在疾病早期阶段，患者和照护伙伴的决定因素都会对照护伙伴的结局产生影响。本研究为高照护伙伴负担提供了警示信号。
