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Synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines halosulfoamidation of [1.1.1]propellane with sodium hypohalites and sulfonamides.

作者信息

Li Zhi, Lan Deyou, Zhou Wei, Li Jiacheng, Zhu Hui, Yu Chuanming, Jiang Xinpeng

机构信息

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, P. R. China.

出版信息

Chem Commun (Camb). 2023 May 16;59(40):6056-6059. doi: 10.1039/d3cc01262j.

DOI:10.1039/d3cc01262j
PMID:37114292
Abstract

Herein, we report a catalyst-free synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines under mild conditions. The reaction involves the use of sodium hypohalites and sulfonamides to generate -halosulfonamides , which subsequently undergo radical addition with [1.1.1]propellane to yield the desired products with suitable functional group tolerance.

摘要

相似文献

1
Synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines halosulfoamidation of [1.1.1]propellane with sodium hypohalites and sulfonamides.
Chem Commun (Camb). 2023 May 16;59(40):6056-6059. doi: 10.1039/d3cc01262j.
2
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6
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Sodium Bicyclo[1.1.1]pentanesulfinate: A Bench-Stable Precursor for Bicyclo[1.1.1]pentylsulfones and Bicyclo- [1.1.1]pentanesulfonamides.螺环[1.1.1]戊烷砜亚磺酸钠：螺环[1.1.1]戊基砜和螺环[1.1.1]戊烷磺酰胺的稳定前体。
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