Synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines halosulfoamidation of [1.1.1]propellane with sodium hypohalites and sulfonamides.

Herein, we report a catalyst-free synthesis of C3-halo substituted bicyclo[1.1.1]pentylamines under mild conditions. The reaction involves the use of sodium hypohalites and sulfonamides to generate -halosulfonamides , which subsequently undergo radical addition with [1.1.1]propellane to yield the desired products with suitable functional group tolerance.