Department of Radiology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Saadat Abad Street, Yadegare Imam Highway, Tehran, 1998734383, Iran.
Department of Urology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abdom Radiol (NY). 2023 Jul;48(7):2361-2369. doi: 10.1007/s00261-023-03921-1. Epub 2023 Apr 28.
The goal of this study was to retrospectively investigate the relationship between renal transplanted volume indexes (Total kidney volume (TKV)/Body surface area (BSA), Renal parenchymal volume (RPV)/BSA, Renal cortical volume (RCV)/BSA, RPV/Body mass index (BMI), RCV/BMI, RPV/Weight, RCV/Weight), and short- and long-term function of the graft.
One-hundred and twelve live donor-recipient pairs from 2017 to 2018, whose donors underwent preoperative renal computed tomography angiography and recipients survived during 12 months of follow-up, were included in this study.
The crude and adjusted linear regressions for the effect of volume measurements by voxel and ellipsoid methods on the estimated glomerular filtration rate (eGFR) at different post-transplantation times demonstrated that the RPV/weight ratio had the most substantial crude effect on the eGFR 12 months and 4 years after renal transplant. Receiver operating characteristic (ROC) curves for six different renal volume ratios demonstrated no significant difference between these ratios in terms of discriminative ability (p value < 0.05). A strong direct correlation between TKV calculated by the ellipsoid formula with RPV and RCV measured using OsiriX software was noted. Analysis of ROC curves for renal volume indices has demonstrated fair to good discriminative ability of our cut-off points to estimate 4-year post-transplantation eGFR > 60 mL/min.
Renal transplant recipients' volume indices, such as RPV/weight, had strong correlations with eGFR at different points in time, and renal transplant recipients with the volume ratios higher than our cut-off points had a good chance of having a 4-year post-transplantation eGFR higher than 60 mL/min.
本研究旨在回顾性研究肾移植体积指标（全肾体积（TKV）/体表面积（BSA）、肾实质体积（RPV）/BSA、肾皮质体积（RCV）/BSA、RPV/体重指数（BMI）、RCV/BMI、RPV/体重、RCV/体重）与移植物短期和长期功能的关系。
纳入了 2017 年至 2018 年期间的 112 对活体供受者，这些供者在术前接受了肾脏计算机断层血管造影术，而受者在 12 个月的随访期间存活。
使用体素和椭圆体方法测量体积对不同移植后时间点估算肾小球滤过率（eGFR）的影响进行的粗线和调整线性回归表明，在肾移植后 12 个月和 4 年，RPV/体重比与 eGFR 具有最显著的粗效应。六种不同肾体积比的受试者工作特征（ROC）曲线表明，这些比率在判别能力方面没有显著差异（p 值<0.05）。用椭圆体公式计算的 TKV 与 OsiriX 软件测量的 RPV 和 RCV 之间存在很强的直接相关性。肾体积指数的 ROC 曲线分析表明，我们的切点在估计 4 年后的移植后 eGFR>60 mL/min 方面具有良好的判别能力。
肾移植受者的体积指数，如 RPV/体重，与不同时间点的 eGFR 有很强的相关性，体积比高于我们的切点的肾移植受者有很大的机会在 4 年后的移植后 eGFR 高于 60 mL/min。
