Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
Clinical medicine, Nankai University, Tianjin, China.
BMJ Open. 2023 Apr 28;13(4):e070312. doi: 10.1136/bmjopen-2022-070312.
Previous research has shown an association of higher heart rate with an increased risk of atrial fibrillation (AF). However, the relationship between resting heart rate (RHR) and AF is unknown. The aim of this study was to investigate the association between RHR and AF in the general population of China.
Prospective observational cohort study.
Community based.
A total of 46 126 individuals from the Kailuan study who participated in the first three surveys (2006/2007, 2008/2009 and 2010/2011) and were followed up at 2-year intervals were enrolled.
The association between RHR and risk of incident AF was evaluated using Cox proportional hazards regression and restricted cubic spline models.
Two hundred and forty-one individuals (0.52%) developed AF during 7.5 years of follow-up. After adjustment for age, sex, low-density and high-density lipoprotein, physical activity, alcohol consumption, smoking status, body mass index, mean systolic blood pressure, and history of diabetes and hypertension, the HRs were 2.32 (95% CI 1.45 to 3.72) for an RHR <60 beats/min and 2.80 (1.13 to 6.94) for an RHR ≥100 beats/min in comparison with an RHR of 70-80 beats/min. Restricted cubic spline models revealed a U-shaped relationship between RHR and incident AF.
These findings indicate that RHR and incident AF have a U-shaped relationship in the Chinese general population. Both lower and higher RHRs were associated with an increased risk of AF.
既往研究显示，心率升高与心房颤动（房颤）风险增加相关。然而，静息心率（RHR）与房颤的关系尚不清楚。本研究旨在探讨中国一般人群中 RHR 与房颤的关系。
前瞻性观察性队列研究。
社区为基础。
共有 46126 名来自开滦研究的个体参加了前三次调查（2006/2007 年、2008/2009 年和 2010/2011 年），并在 2 年的随访间隔内进行了随访。
使用 Cox 比例风险回归和限制三次样条模型评估 RHR 与新发房颤风险之间的关系。
在 7.5 年的随访期间，241 人（0.52%）发生房颤。在校正年龄、性别、低密度脂蛋白和高密度脂蛋白、体力活动、饮酒、吸烟状况、体重指数、平均收缩压以及糖尿病和高血压病史后，与 RHR 为 70-80 次/分相比，RHR<60 次/分的 HR 为 2.32（95%CI 1.45 至 3.72），RHR≥100 次/分的 HR 为 2.80（1.13 至 6.94）。限制三次样条模型显示 RHR 与新发房颤之间呈 U 型关系。
这些发现表明，在中国一般人群中，RHR 与房颤发生呈 U 型关系。较低和较高的 RHR 均与房颤风险增加相关。
