Jouve R, Puddu P E, Langlet F, Guillen J C, Serradimigni A
J Electrocardiol. 1986 Apr;19(2):155-64. doi: 10.1016/s0022-0736(86)80023-1.
This study deals with a left circumflex coronary artery occlusion-reperfusion canine model of sudden death using multiple electrocardiographic leads to define a subgroup of animals at high risk of ventricular fibrillation. Occlusion was followed by ventricular fibrillation in 15 of 30 animals (50%). In the 15 dogs surviving 60 min postocclusion, reperfusion gave rise to ten cases of ventricular fibrillation (66.7%). Thus, the total incidence of occlusion-reperfusion ventricular fibrillation was 25 of 30 (83.3%). Electrocardiographic delta R% changes greater than or equal to 25% in leads 2 and 3 at both 3 and 5 min postocclusion predicted the occurrence of postocclusion ventricular fibrillation with 80% specificity and 56% sensitivity. However, ST segment elevation greater than or equal to 0.5 mV in the same leads at the same times predicted postocclusion ventricular fibrillation with 67% specificity and 100% sensitivity. When only dogs with ST segment elevation greater than or equal to 0.5 mV in leads 2 and 3 at both 3 and 5 min postocclusion were considered, ventricular fibrillation postocclusion was seen in 15 of 20 dogs (75%) and ventricular fibrillation after reperfusion occurred in four of the remaining five animals (80%). Thus, in the subgroup of animals presenting with ST segment elevation greater than or equal to 0.5 mV in leads 2 and 3 at both 3 and 5 min postocclusion, the overall incidence of occlusion-reperfusion ventricular fibrillation was 19 of 20 (95%). These data may be useful in studies aimed at testing the effectiveness of drugs or other interventions in a canine model of sudden death.
本研究采用多导联心电图对左回旋支冠状动脉闭塞-再灌注致猝死犬模型进行研究，以确定心室颤动高危动物亚组。30只动物中有15只（50%）在闭塞后发生心室颤动。在闭塞后存活60分钟的15只犬中，再灌注导致10例心室颤动（66.7%）。因此，闭塞-再灌注心室颤动的总发生率为30只中的25只（83.3%）。闭塞后3分钟和5分钟时，导联2和导联3的心电图δR%变化大于或等于25%，预测闭塞后心室颤动发生的特异性为80%，敏感性为56%。然而，相同导联在相同时间ST段抬高大于或等于0.5mV，预测闭塞后心室颤动的特异性为67%，敏感性为100%。仅考虑闭塞后3分钟和5分钟时导联2和导联3的ST段抬高大于或等于0.5mV的犬，20只中有15只（75%）出现闭塞后心室颤动，其余5只中有4只（80%）在再灌注后发生心室颤动。因此，在闭塞后3分钟和5分钟时导联2和导联3的ST段抬高大于或等于0.5mV的动物亚组中，闭塞-再灌注心室颤动的总发生率为20只中的19只（95%）。这些数据可能有助于旨在测试药物或其他干预措施在犬猝死模型中有效性的研究。
