Iansek R, Packham D, Aspey B S, Harrison M J
J Neurol Neurosurg Psychiatry. 1986 May;49(5):585-7. doi: 10.1136/jnnp.49.5.585.
Allopurinol has been shown to have a protective effect on ischaemic tissue by the indirect prevention of excessive purine loss. This property was tested in the gerbil model of acute stroke. A total of 69 animals were pretreated with an intraperitoneal injection of either allopurinol (50 mg/kg) or sterile water and then subjected to unilateral ligation of the left common carotid artery under general anaesthesia. The clinical effect of the ligation was grouped into three categories of normal, mild to moderate defect (splayed leg, turning behaviour) and severe defect (death, nonresponsiveness and seizures). More normal animals and fewer severely affected animals were present in the allopurinol treated group compared to controls, but only at 2 to 4 hours after carotid ligation (p less than 0.05). Histological examination of brain tissue from the normal category failed to reveal any difference in subclinical ischaemic damage between the two groups. It was concluded that allopurinol may have a protective effect in acute stroke and that this property warrants further elucidation.
已表明别嘌呤醇通过间接预防过多嘌呤损失，对缺血组织具有保护作用。在急性中风的沙鼠模型中对该特性进行了测试。总共69只动物腹腔注射别嘌呤醇（50毫克/千克）或无菌水进行预处理，然后在全身麻醉下对左颈总动脉进行单侧结扎。结扎的临床效果分为正常、轻度至中度缺陷（腿部外展、转向行为）和严重缺陷（死亡、无反应和癫痫发作）三类。与对照组相比，别嘌呤醇治疗组中正常动物更多，严重受影响的动物更少，但仅在颈动脉结扎后2至4小时出现这种情况（p小于0.05）。对正常类别的脑组织进行组织学检查，未发现两组之间亚临床缺血损伤有任何差异。得出的结论是，别嘌呤醇可能对急性中风具有保护作用，这一特性值得进一步阐明。
