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血清素与白细胞介素18在急性冠脉综合征患者自杀倾向中的潜在联系

Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome.

作者信息

Kim Jae-Min, Kang Hee-Ju, Kim Ju-Wan, Choi Wonsuk, Kim Sung-Wan, Kim Jung-Chul, Chun Byung Jo, Ahn Youngkeun, Jeong Myung Ho

机构信息

Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.

Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

出版信息

Clin Psychopharmacol Neurosci. 2023 May 30;21(2):386-390. doi: 10.9758/cpn.2023.21.2.386.

DOI:10.9758/cpn.2023.21.2.386
PMID:37119231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10157011/
Abstract

OBJECTIVE

We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).

METHODS

Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.

RESULTS

Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.

CONCLUSION

By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.

摘要

目的

我们研究了血清5-羟色胺和白细胞介素18水平在急性冠状动脉综合征（ACS）急性期和慢性期对自杀观念（SI）的影响。

方法

对969例近期发病的ACS患者进行血清5-羟色胺和白细胞介素18水平评估，并通过蒙哥马利-Åsberg抑郁评定量表的“自杀想法”项目评估自杀观念。1年后，对711例患者的自杀观念进行重新评估。采用逻辑回归模型对潜在协变量进行校正。

结果

仅在血清5-羟色胺水平较低的组中，血清白细胞介素18与两个阶段的自杀观念之间的关联具有显著性。

结论

通过评估血清5-羟色胺和白细胞介素18水平，可能会改善ACS患者自杀观念的临床预测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9a/10157011/1fcfdd4299e4/cpn-21-2-386-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9a/10157011/1fcfdd4299e4/cpn-21-2-386-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec9a/10157011/1fcfdd4299e4/cpn-21-2-386-f1.jpg

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