甲状腺的造釉细胞瘤样尤因肉瘤——一种不常见的头颈部上皮和间叶肿瘤的模仿者。
Adamantinoma-like Ewing sarcoma of thyroid gland-An unfamiliar mimicker of epithelial and mesenchymal neoplasms of the head and neck.
作者信息
Mohammed I, Baskovich B, Alkhasawneh A, Gopinath A
机构信息
University of Florida College of Medicine Jacksonville, Department of Pathology, 655 W, 8th street, Jacksonville, Florida, USA 33209.
出版信息
Malays J Pathol. 2023 Apr;45(1):129-134.
INTRODUCTION
Adamantinoma-like Ewing Sarcoma (ALES) is a rare variant of the Ewing family of tumours (EFT) harbouring the EWSR1-FLI1 translocation and with complex epithelial differentiation. Very few cases of ALES involving thyroid have been reported in literature.
CASE REPORT
We report a case of ALES involving the thyroid in a 61-year-old male who presented with an enlarging nodule in the left lobe of the thyroid and underwent hemithyroidectomy.
DISCUSSION
ALES demonstrates morphologic similarity to a multitude of epithelial and mesenchymal tumours, creating a potential diagnostic pitfall in thyroid and head and neck pathology. Given the rarity of this tumour, there is also a lack of accepted guidelines regarding further surgical management of these cases following hemithyroidectomy.
引言
类 adamantinoma 的尤因肉瘤（ALES）是尤因肿瘤家族（EFT）的一种罕见变体，具有 EWSR1 - FLI1 易位且伴有复杂的上皮分化。文献中报道的累及甲状腺的 ALES 病例极少。
病例报告
我们报告一例 61 岁男性的 ALES 累及甲状腺，该患者因甲状腺左叶结节增大就诊并接受了甲状腺半叶切除术。
讨论
ALES 在形态学上与多种上皮和间叶性肿瘤相似，这在甲状腺及头颈部病理学中可能造成诊断陷阱。鉴于这种肿瘤的罕见性，对于这些病例在甲状腺半叶切除术后的进一步手术管理也缺乏公认的指导原则。
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