Department of Neurosurgery, University of Florida College of Medicine, Gainesville, Florida, USA.
Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
World Neurosurg. 2023 Jul;175:e1186-e1190. doi: 10.1016/j.wneu.2023.04.095. Epub 2023 Apr 28.
Within the trauma spine surgery literature, the effect of patient frailty on postoperative outcomes for posterior spinal fusion (PSF) remains clear. In this study, the authors quantified the influence of the 5-factor modified frailty index (mFI-5) score on hospital length of stay, diagnosis of a postoperative infection, 30-day readmission, and 90-day return to operating room (OR).
The authors retrospectively reviewed the records of all patients with traumatic spine injury undergoing PSF by a single surgeon at our institution from 2016 to 2021. Data were extracted using manual chart review and the mFI-5 score was calculated using data on comorbidities. Bivariate (Mann-Whitney U test and Fisher exact test) and multivariate regressions (linear and logistic) revealed whether there was an independent relationship between patient frailty and postoperative outcomes.
The patient cohort included 263 patients (52.00 ± 19.04), 67 (25.5) were classified as frail, defined as having an mFI-5 score ≥2. Patients who were classified as frail were significantly more likely to have diabetes (odds ratio = 21.53; P < 0.001) and active cancer (odds ratio = 10.03; P = 0.004). Patients with mFI-5 scores ≥2 were also significantly older (P < 0.001) and had higher body mass index (BMI) (P = 0.007). Patients with mFI-5 scores >2 were more likely to return to the OR (odds ratio = 2.43; P = 0.037) on bivariate analysis. When controlling for demographics and clinical characteristics, mFI-5 score independently predicted return to OR (odds ratio = 1.294; P = 0.041).
Patient frailty independently predicted a return to OR in patients undergoing PSF for traumatic spine injury. Future studies can investigate methods for patient risk optimization to reduce morbidity and mortality.
在创伤脊柱外科文献中,患者脆弱性对后路脊柱融合术(PSF)术后结果的影响是明确的。在这项研究中,作者量化了 5 因素改良衰弱指数(mFI-5)评分对住院时间、术后感染诊断、30 天再入院和 90 天重返手术室(OR)的影响。
作者回顾性分析了 2016 年至 2021 年间,由一名外科医生对我院创伤性脊柱损伤患者进行 PSF 的记录。通过手动图表审查提取数据,并使用合并症数据计算 mFI-5 评分。使用双变量(Mann-Whitney U 检验和 Fisher 确切检验)和多变量回归(线性和逻辑)来揭示患者脆弱性与术后结果之间是否存在独立关系。
患者队列包括 263 名患者(52.00±19.04),67 名(25.5%)被归类为脆弱,定义为 mFI-5 评分≥2。被归类为脆弱的患者更有可能患有糖尿病(优势比=21.53;P<0.001)和活动性癌症(优势比=10.03;P=0.004)。mFI-5 评分≥2 的患者年龄也明显更大(P<0.001),体重指数(BMI)更高(P=0.007)。mFI-5 评分>2 的患者更有可能在二次分析中返回 OR(优势比=2.43;P=0.037)。当控制人口统计学和临床特征时,mFI-5 评分独立预测返回 OR(优势比=1.294;P=0.041)。
患者脆弱性独立预测了创伤性脊柱损伤患者行 PSF 后返回 OR。未来的研究可以探讨患者风险优化的方法,以降低发病率和死亡率。