Mikhael N Z, Boggs M, Kacew S, Potvin D L
J Environ Pathol Toxicol Oncol. 1986 Mar-Apr;6(3-4):345-50.
Autopsy tissue examination was employed as a measure to remove subjective bias observation in the identification and numerical computation of adverse reactions to drugs. With the the use of this novel technique, the incidence of adverse reactions was 26%, of which 82% were produced by a specific causative agent. Adverse reactions occurred most frequently in autopsied tissues taken from patients who were male and in the 61 and over age group. Further the predominant tissue altered morphologically in autopsied specimens examined was liver. The most common causative agent associated with an adverse tissue reaction was identified as alcohol. In light of the difference between evaluation by physicians of drug adverse reactions and the technique of autopsy tissue examination, our findings provide a more accurate measure of adverse reactions to non-prescription pharmacological agents.
尸检组织检查被用作一种措施，以消除在药物不良反应识别和数值计算中主观偏差观察。通过使用这种新技术，不良反应发生率为26%，其中82%由特定病原体引起。不良反应最常发生在61岁及以上男性患者的尸检组织中。此外，在检查的尸检标本中形态学改变最主要的组织是肝脏。与不良组织反应相关的最常见病原体被确定为酒精。鉴于医生对药物不良反应的评估与尸检组织检查技术之间的差异，我们的发现为非处方药物制剂的不良反应提供了更准确的衡量标准。
