取代的1-苄基咪唑-2-硫醇作为多巴胺β-羟化酶的强效口服活性抑制剂。 - Suppr

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超能文献

Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase.

作者信息

Kruse L I, Kaiser C, DeWolf W E, Frazee J S, Erickson R W, Ezekiel M, Ohlstein E H, Ruffolo R R, Berkowitz B A

出版信息

J Med Chem. 1986 Jun;29(6):887-9. doi: 10.1021/jm00156a002.

DOI:10.1021/jm00156a002

PMID:3712378

Abstract

摘要

相似文献

Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase.取代的1-苄基咪唑-2-硫醇作为多巴胺β-羟化酶的强效口服活性抑制剂。

J Med Chem. 1986 Jun;29(6):887-9. doi: 10.1021/jm00156a002.

1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine beta-hydroxylase.1-（噻吩基烷基）咪唑-2（3H）-硫酮作为多巴胺β-羟化酶的强效竞争性抑制剂

J Med Chem. 1990 Jul;33(7):1866-73. doi: 10.1021/jm00169a006.

Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site.多巴胺β-羟化酶的多底物抑制剂。2. 苯乙胺结合位点的构效关系。

J Med Chem. 1987 Mar;30(3):486-94. doi: 10.1021/jm00386a008.

Inhibitors of dopamine beta-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2-thiones.多巴胺β-羟化酶抑制剂。3. 一些1-（吡啶基甲基）咪唑-2-硫酮。

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Cardiovascular effects of a new potent dopamine beta-hydroxylase inhibitor in spontaneously hypertensive rats.一种新型强效多巴胺β-羟化酶抑制剂对自发性高血压大鼠的心血管作用。

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Influence of dopamine-beta-hydroxylase inhibition on the cardiovascular and respiratory actions of dopamine in rats.多巴胺-β-羟化酶抑制对大鼠体内多巴胺心血管及呼吸作用的影响。

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Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase.β-取代苯乙胺作为基于机制的多巴胺β-羟化酶高亲和力抑制剂。

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Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.奈匹卡酯（RS-25560-197）是一种新型、强效且选择性的多巴胺-β-羟化酶抑制剂，其儿茶酚胺调节作用。

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Comparison of centrally mediated hypotensive action of methyldopa and DOPA in cats.甲基多巴与多巴对猫中枢介导的降压作用比较

Arch Int Pharmacodyn Ther. 1973 Sep;205(1):103-13.

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