Szekeres L, Boros E, Pataricza J, Udvary E
J Mol Cell Cardiol. 1986 Apr;18(4):369-73. doi: 10.1016/s0022-2828(86)80900-2.
In the present experiments the dominant role in the genesis of arrhythmias of stimulation of beta adrenoceptors over that of alpha adrenoceptors has been demonstrated by: (i) infusion of catecholamines in the isolated right ventricular Purkinje fiber preparation of rabbits; and (ii) by subepicardial microinfusion of these substances to anesthetized thoracotomized dogs. Activation of the latent pacemaker areas by local myocardial ischemia was shown. Catecholamine-induced arrhythmias also resulted from premature excitation of the working myocardium as a consequence of an interaction of Purkinje firing and excitation originating from higher pacemaker areas.
在目前的实验中，通过以下方式证明了在心律失常的发生过程中，β肾上腺素能受体刺激比α肾上腺素能受体刺激起主导作用：（i）在兔离体右心室浦肯野纤维标本中注入儿茶酚胺；（ii）在麻醉开胸犬的心外膜下微量注入这些物质。显示了局部心肌缺血激活潜在起搏点区域。儿茶酚胺诱发的心律失常也是由于浦肯野纤维放电与来自较高起搏点区域的兴奋相互作用，导致工作心肌过早兴奋所致。
