Hsu W H, Hopper D L
J Toxicol Environ Health. 1986;18(3):423-9. doi: 10.1080/15287398609530882.
Yohimbine was studied to examine its effectiveness in preventing central nervous system(CNS) depression and bradycardia induced by amitraz (N'-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl-imino)-methyl]-N-methyl- methanimide). In control open-field activity experiments, the dogs showed high numbers of grid-line crossings in the first 5 min (exploratory phase), and subsequently low numbers of grid-line crossings (nonexploratory phase). An iv injection of amitraz (1 mg/kg) abolished both the exploratory and nonexploratory phases and caused bradycardia. Yohimbine alone caused a trend to increase the open-field activity in the nonexploratory phase. In addition, yohimbine prevented the bradycardia and suppression of open-field activity induced by amitraz. The results suggest that yohimbine has a potential to be used as an antidote for amitraz overdose.
研究了育亨宾预防由双甲脒（N'-（2,4-二甲基苯基）-N-[(2,4-二甲基苯基亚氨基）甲基]-N-甲基甲亚胺）引起的中枢神经系统（CNS）抑制和心动过缓的有效性。在对照旷场活动实验中，犬在最初5分钟（探索期）跨越网格线的次数较多，随后跨越网格线的次数较少（非探索期）。静脉注射双甲脒（1毫克/千克）消除了探索期和非探索期，并导致心动过缓。单独使用育亨宾有增加非探索期旷场活动的趋势。此外，育亨宾可预防双甲脒引起的心动过缓和旷场活动抑制。结果表明，育亨宾有潜力用作双甲脒过量的解毒剂。
