USTHB, Faculty of Biological Sciences, Laboratory of Cellular & Molecular Biology, BP 32, El-Alia, Bab Ezzouar, 16111, Algiers, Algeria.
Nanomedicine (Lond). 2023 Feb;18(4):367-390. doi: 10.2217/nnm-2022-0188. Epub 2023 Apr 26.
The objective of this study was to investigate the therapeutic potential of quercetin (QT) and QT-loaded poly(lactic-co-glycolic acid) nanoparticles (QT-NPs) on venom-mediated inflammation, redox imbalance, hepatorenal tissue damage and local hemorrhage. The developed QT-NPs were first submitted to physicochemical characterization and then evaluated in the 'challenge then treat' and 'preincubation' models of envenoming. QT-NPs efficiently alleviated hepatorenal toxicity, inflammation and redox imbalance and significantly attenuated venom-induced local hemorrhage. Interestingly, QT-NPs were significantly more efficient than free QT at 24 h postenvenoming, pointing to the efficacy of this drug-delivery system. These findings highlight the therapeutic potential of QT-NPs on venom-induced toxicity and open up the avenue for their use in the management of snakebite envenoming.
本研究旨在探究槲皮素（QT）及其负载于聚乳酸-羟基乙酸共聚物纳米粒（QT-NPs）对毒液介导的炎症、氧化还原失衡、肝肾功能损伤和局部出血的治疗潜力。首先对所制备的 QT-NPs 进行理化特性表征，然后在毒液攻击的“先攻后治”和“预孵育”模型中进行评价。QT-NPs 可有效缓解肝肾功能损伤、炎症和氧化还原失衡，并显著减轻毒液引起的局部出血。有趣的是，与 24 h 后攻毒的游离 QT 相比，QT-NPs 的疗效更显著，表明该给药系统具有疗效。这些发现突出了 QT-NPs 在治疗毒液诱导的毒性方面的潜力，并为其在蛇伤治疗中的应用开辟了道路。
