Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Transplant Proc. 2023 May;55(4):985-989. doi: 10.1016/j.transproceed.2023.03.049. Epub 2023 Apr 29.
Cytomegalovirus (CMV) is one of the most frequent infections after pancreas transplantation (PTx), and it is unclear whether CMV infection is associated with pancreas graft loss. A limited number of studies about the relationship between CMV infection and pancreas graft loss have been reported from Western countries, but there have been no reports from Japan. This study investigated the relationship between CMV infection and pancreas graft loss after PTx in a single Japanese institution.
This study included 58 patients who underwent PTx from deceased donors from April 2000 to March 2021 in our institution. We assessed pancreas graft loss based on CMV infection and disease and investigated the causes of graft loss, the time of onset of CMV disease, and the time of graft loss for each case.
The numbers of patients in the 4 categories of donor (D) and recipient (R) pretransplant anti-CMV antibody status were as follows: 4 (6.9%) in the D-/R- group, 6 (10.3%) in the D-/R+ group, 34 (58.6%) in the D+/R+ group, and 14 (24.1%) in the D+/R- group. Of the 58 patients, 74.1% and 44.1% received diagnoses of CMV infection and disease after PTx, respectively. There were no significant differences in the survival rates of pancreas graft loss stratified by CMV infection (P = .1809) or disease (P = .6241).
This study suggests that CMV infection and disease had no significant influence on pancreas graft loss in this Japanese institution.
巨细胞病毒（CMV）是胰腺移植（PTx）后最常见的感染之一，目前尚不清楚 CMV 感染是否与胰腺移植物丧失有关。少数来自西方国家的研究报告了 CMV 感染与胰腺移植物丧失之间的关系，但来自日本的报告尚未出现。本研究在日本的一家机构中调查了 CMV 感染与 PTx 后胰腺移植物丧失之间的关系。
本研究纳入了 2000 年 4 月至 2021 年 3 月期间在我院接受尸源供体 PTx 的 58 例患者。我们根据 CMV 感染和疾病评估胰腺移植物丧失，并调查了每个病例的移植物丧失原因、CMV 疾病的发病时间和移植物丧失时间。
供体（D）和受体（R）移植前抗 CMV 抗体状态的患者数量如下：D-/R-组 4 例（6.9%），D-/R+组 6 例（10.3%），D+/R+组 34 例（58.6%），D+/R-组 14 例（24.1%）。58 例患者中，74.1%和 44.1%分别在 PTx 后诊断为 CMV 感染和疾病。CMV 感染（P=0.1809）或疾病（P=0.6241）分层后，胰腺移植物丧失的存活率无显著差异。
本研究表明，CMV 感染和疾病在该日本机构中对胰腺移植物丧失没有显著影响。
