[Clinicopathological studies on cases of multiple primary carcinomas of the esophagus associated with carcinoma of the hypopharynx and cervical esophagus].

Four cases of multiple primary carcinoma of the esophagus associated with dysplasia were found among seven patients with squamous cell carcinoma of the hypopharynx and cervical esophagus at the Shikoku Cancer Center Hospital. Two minute carcinomas were observed in these cases. One of them was too small to detect clinically despite the application of esophagoscopy with the Lugol's solution spraying method. All four patients had continued to smoke and consume alcoholic beverages (regularly) (habitually). These findings suggested that total esophagectomy is applicable to patients with hypopharyngoesophageal cancer, particularly those who continue to drink and smoke regularly.