Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic of China.
Future Oncol. 2023 Mar;19(10):715-726. doi: 10.2217/fon-2023-0083. Epub 2023 May 2.
This retrospective study aimed to evaluate the effect of age on cancer relapse and survival in breast cancer patients undergoing different treatments. The propensity score method was used to correct for disparities between two groups; 2049 young patients were matched to 4053 older patients. Kaplan-Meier curves and Cox proportional hazards models were used to assess disease-free survival. In the original cohort, young patients showed higher lymph node metastasis, hormone-receptor positivity and high Ki-67 levels. After propensity score matching, the disease-free survival of young patients with the luminal B-like subtype who received mastectomy with early stage disease exhibited inferior survival. Decisions about biology-driven systemic treatment strategies for young patients are worthy of discussion with a multidisciplinary tumor board.
本回顾性研究旨在评估年龄对接受不同治疗的乳腺癌患者癌症复发和生存的影响。采用倾向评分法校正两组间的差异；将 2049 例年轻患者与 4053 例老年患者进行匹配。采用 Kaplan-Meier 曲线和 Cox 比例风险模型评估无病生存。在原始队列中，年轻患者表现出更高的淋巴结转移、激素受体阳性和高 Ki-67 水平。在倾向评分匹配后，早期疾病接受乳房切除术的 luminal B 样亚型的年轻患者的无病生存显示出较差的生存。年轻患者的生物学驱动的系统治疗策略决策值得与多学科肿瘤委员会讨论。
