School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, People's Republic of China.
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506-0055, USA.
Chem Commun (Camb). 2023 May 18;59(41):6215-6218. doi: 10.1039/d3cc01268a.
Garcinielliptone FC (GFC) was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) and was found to exhibit diverse biological activities. Now we revise the structure of GFC to xanthochymol, a type B PPAP, NMR and total synthesis methods. The total syntheses of (±)-xanthochymol and (±)-cycloxanthochymol were accomplished in 12 and 13 steps, respectively.
Garcinielliptone FC (GFC) 被归类为 A 型多环聚异戊烯基酰基间苯三酚（PPAP），并被发现具有多种生物活性。现在我们将 GFC 的结构修订为黄烷醇，一种 B 型 PPAP，使用 NMR 和全合成方法。(±)-黄烷醇和 (±)-环黄烷醇的全合成分别通过 12 步和 13 步完成。
