Department of Infectious Diseases, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, China.
J Viral Hepat. 2023 Aug;30(8):638-645. doi: 10.1111/jvh.13840. Epub 2023 May 2.
The replication of HBV in hepatocytes can be effectively inhibited by lifelong antiviral therapy. Because of the long-term presence of HBV reservoirs, the virus rebound frequently occurs once the treatment is stopped, which poses a considerable obstacle to the complete removal of the virus. In terms of gene composition, regulation of B cell action and function, CXCR5 CD8 T cells are similar to CXCR5 CD4 T follicular helper cells, while these cells are characterized by elevated programmed cell death 1 and cytotoxic-related proteins. CXCR5 CD8 T cells are strongly associated with progression in inflammatory and autoimmune diseases. In addition, CXCR5 expression on the surface of CD8 T cells is mostly an indicator of memory stem cell-like failure in progenitor cells in cancer that are more responsive to immune checkpoint blocking therapy. Furthermore, the phenomena have also been demonstrated in some viral infections, highlighting the duality of the cellular immune response of CXCR5 CD8 T cells. This mini-review will focus on the function of CXCR5 CD8 T cells in HBV infection and discuss the function of these CD8 T cells and the potential of associated co-stimulators or cytokines in HBV therapeutic strategies.
HBV 在肝细胞中的复制可以通过终身抗病毒治疗得到有效抑制。由于 HBV 储存库的长期存在，一旦停止治疗，病毒经常会反弹，这对彻底清除病毒构成了相当大的障碍。在基因组成、B 细胞作用和功能的调节方面，CXCR5 CD8 T 细胞与 CXCR5 CD4 滤泡辅助 T 细胞相似，而这些细胞的特征是程序性细胞死亡 1 和细胞毒性相关蛋白水平升高。CXCR5 CD8 T 细胞与炎症和自身免疫性疾病的进展密切相关。此外，CD8 T 细胞表面的 CXCR5 表达大多是癌症中祖细胞中记忆干细胞样衰竭的标志物，这些祖细胞对免疫检查点阻断治疗更敏感。此外，这些现象在一些病毒感染中也得到了证实，突出了 CXCR5 CD8 T 细胞的细胞免疫反应的双重性。本综述将重点讨论 CXCR5 CD8 T 细胞在 HBV 感染中的作用，并讨论这些 CD8 T 细胞的功能以及相关共刺激分子或细胞因子在 HBV 治疗策略中的潜力。
