[Tissue and bacterial sensitization in patients with bone pathology].

The author studied sensitization to normal tissues (bone, muscle, spleen) and tissues altered by pathological process (sequestrum, scars), and also to allergens of widespread causative agents of purulent infection (staphylococcus, streptococcus, Proteus, E. coli) in 87 patients with different bone pathology and in 24 donors. Leukocytolysis reaction (modified by Karapaty) was used for ascertaining the sensitization; a total of 592 tests were conducted. With the development of infection in soft tissues and then in the bone there was an increase in frequency of positive reactions and their manifestation in interaction with the antigens of both normal tissues and those altered by pathological process. The incidence of positive reactions and their manifestation with bacterial allergens coinciding with the microbial flora of the focus of infection was also increased.