Department of Geriatrics, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China.
Department of Geriatrics, Xuzhou medical university affiliated the hospital of Lianyungang, Lianyungang, Jiangsu, China.
Biotechnol Genet Eng Rev. 2024 Dec;40(4):3874-3883. doi: 10.1080/02648725.2023.2204605. Epub 2023 May 2.
To investigate the correlation between the coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease. 415 patients with hypertension complicated by cerebral small vessel disease who received treatment in our hospital from January 2019 to June 2022 were retrospectively included in this study. These patients were divided into a cognitive dysfunction group ( = 74) and a non-cognitive dysfunction group ( = 341) according to whether they had cognitive dysfunction. Blood pressure and general data were recorded for each patient. The logistic regression coefficient was used to analyze the correlation between coefficient of variation of blood pressure and cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease. Multivariate logistic regression analysis showed that age, the weighted standard deviation of 24-hour systolic blood pressure (24hSBP-wSD), cholesterol level, and triglyceride level were risk factors for cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease ( < 0.05). The risk for cognitive dysfunction was increased by 3.532-fold in patients aged>65 years, increased by 1.203-fold in patients with a 24hSBP-wSD of 14.9-15.9%, and increased by 3.033-fold in patients with a 24hSBP-wSD>16.0% ( < 0.05). The coefficient of variation of blood pressure is markedly correlated with the risk for cognitive dysfunction; and a higher coefficient of variation of blood pressure leads to a higher risk for cognitive dysfunction in patients with hypertension complicated by cerebral small vessel disease.
探讨高血压合并脑小血管病患者血压变异系数与认知功能障碍的相关性。
回顾性纳入 2019 年 1 月至 2022 年 6 月在我院治疗的 415 例高血压合并脑小血管病患者，根据是否存在认知功能障碍，将这些患者分为认知功能障碍组（ = 74）和非认知功能障碍组（ = 341）。记录每位患者的血压和一般资料。采用 logistic 回归系数分析高血压合并脑小血管病患者血压变异系数与认知功能障碍的相关性。
多因素 logistic 回归分析显示，年龄、24 小时收缩压加权标准差（24hSBP-wSD）、胆固醇水平和甘油三酯水平是高血压合并脑小血管病患者认知功能障碍的危险因素（ < 0.05）。年龄>65 岁的患者认知功能障碍风险增加 3.532 倍，24hSBP-wSD 为 14.9-15.9%的患者认知功能障碍风险增加 1.203 倍，24hSBP-wSD>16.0%的患者认知功能障碍风险增加 3.033 倍（ < 0.05）。
血压变异系数与认知功能障碍的风险显著相关；血压变异系数越高，高血压合并脑小血管病患者发生认知功能障碍的风险越高。
