Cardiology Department, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China.
Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230000, China.
BMC Cardiovasc Disord. 2023 May 2;23(1):228. doi: 10.1186/s12872-023-03229-4.
As a novel marker of insulin resistance, the ratio of triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) has been recently reported to be related to the occurrence of coronary artery diseases. However, no research has been conducted to probe whether the TG/HDL-C ratio is associated with the occurrence of coronary microvascular disease (CMVD).
This study investigates the association between the TG/HDL-C ratio and the occurrence of CMVD.
This study included 175 patients diagnosed with CMVD in the Department of Cardiology of our hospital from October 2017 to October 2021 as the study group and 175 patients with no chest pain, no history of cardiovascular disease and drug use, and negative results of exercise treadmill testing as the non-CMVD group. The clinical data of the two groups were compared. In addition, the risk factors of CMVD were analyzed with logistic regression, and the efficacy of independent risk factors in predicting CMVD was analyzed with a receiver operating characteristic (ROC) curve.
Compared with those in the non-CMVD group, the proportion of females, the incidence of hypertension and type 2 diabetes, the level of platelet count, TG, and C-reactive protein, and the ratio of TG/HDL-C were increased in the CMVD group, accompanied by decreased levels of albumin and HDL-C (P < 0.05). Logistic regression results revealed C-reactive protein (the area under the ROC curve [AUC] value: 0.754; 95% confidence interval [CI]: 0.681-0.827), sex (the AUC value: 0.651; 95%CI: 0.571-0.730), albumin (the AUC value: 0.722; 95%CI: 0.649-0.794), and TG/HDL-C ratio (the AUC value: 0.789; 95%CI: 0.718-0.859) as the independent risk factors of CMVD.
The TG/HDL-C ratio is an independent risk factor for the occurrence of CMVD.
作为胰岛素抵抗的一种新型标志物，甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）比值最近被报道与冠状动脉疾病的发生有关。然而，尚未有研究探讨 TG/HDL-C 比值与冠状动脉微血管疾病（CMVD）的发生是否相关。
本研究旨在探讨 TG/HDL-C 比值与 CMVD 发生之间的关系。
本研究纳入了 2017 年 10 月至 2021 年 10 月期间在我院心内科诊断为 CMVD 的 175 例患者作为研究组，以及 175 例无胸痛、无心血管疾病病史和药物使用史且运动平板试验结果为阴性的患者作为非 CMVD 组。比较两组患者的临床资料。此外，采用 logistic 回归分析 CMVD 的危险因素，并采用受试者工作特征（ROC）曲线分析独立危险因素对 CMVD 的预测效果。
与非 CMVD 组相比，CMVD 组女性比例、高血压和 2 型糖尿病发生率、血小板计数、TG 和 C 反应蛋白水平以及 TG/HDL-C 比值升高，白蛋白和 HDL-C 水平降低（P<0.05）。logistic 回归结果显示，C 反应蛋白（ROC 曲线下面积[AUC]值：0.754；95%置信区间[CI]：0.681-0.827）、性别（AUC 值：0.651；95%CI：0.571-0.730）、白蛋白（AUC 值：0.722；95%CI：0.649-0.794）和 TG/HDL-C 比值（AUC 值：0.789；95%CI：0.718-0.859）是 CMVD 的独立危险因素。
TG/HDL-C 比值是 CMVD 发生的独立危险因素。
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