College of Pharmacy, AL Bayan University, Baghdad, Iraq.
Department of Physiology, College of Medicine, Al Nahrain University, Baghdad, Iraq.
J Med Life. 2023 May;16(5):668-674. doi: 10.25122/jml-2022-0239.
Insulin resistance (IR) is a common pathophysiological condition associated with many metabolic diseases, including obesity, prediabetes, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The widely used homeostasis model assessment for IR (HOMA-IR) is usually used to estimate IR. However, this model cannot be used for screening IR due to several logistic difficulties, such as costs and insulin instability, which are essential for measurement. Thus, finding feasible alternatives is of paramount importance. This study aimed to evaluate the value of triglyceride/high-density lipoprotein-cholesterol (TG/HDL-c) ratio in predicting IR in healthy adult individuals. The study involved 83 euglycemic non-diabetic adults (≥45 years old). Lipid profile, fasting insulin, fasting blood sugar (FBS), and glycated hemoglobin were measured for all participants. The TG/HDL-c ratio was calculated by dividing TG by HDL. Insulin resistance was calculated using the HOMA-IR formula. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the TG/HDL-c ratio. The prevalence of IR among healthy adult Iraqis was 28.92%. Subjects in the IR group showed a higher TG/HDL ratio than the insulin-sensitive group (3.69±0.68 versus 2.71±1.0) with a significant difference. The area under the curve (AUC) for this ratio was 0.849, 95% CI= 0.763-0.935, p<0.002. The sensitivity and specificity of the test were 83% and 81%, respectively, at a best cut-off value of 3.1 (TG/HDL ratio). The prevalence of IR among healthy adult Iraqis was 28.92%. Triglyceride/HDL-c ratio had a very good predictive value for IR.
胰岛素抵抗（IR）是一种与多种代谢疾病相关的常见病理生理状态，包括肥胖、糖尿病前期、2 型糖尿病（T2DM）和心血管疾病。广泛使用的胰岛素抵抗稳态模型评估（HOMA-IR）通常用于估计 IR。然而，由于成本和胰岛素不稳定性等几个逻辑困难，该模型不能用于筛选 IR，这对于测量是必不可少的。因此，寻找可行的替代方法至关重要。本研究旨在评估甘油三酯/高密度脂蛋白胆固醇（TG/HDL-c）比值在预测健康成年人群中 IR 的价值。该研究纳入了 83 名血糖正常的非糖尿病成年人（≥45 岁）。所有参与者均测量了血脂谱、空腹胰岛素、空腹血糖（FBS）和糖化血红蛋白。TG/HDL-c 比值通过 TG 除以 HDL 计算。使用 HOMA-IR 公式计算胰岛素抵抗。使用受试者工作特征（ROC）曲线评估 TG/HDL-c 比值的预测价值。IR 在健康成年伊拉克人中的患病率为 28.92%。IR 组的受试者 TG/HDL-c 比值高于胰岛素敏感组（3.69±0.68 与 2.71±1.0），差异有统计学意义。该比值的曲线下面积（AUC）为 0.849，95%CI=0.763-0.935，p<0.002。最佳截断值为 3.1 时，该检测的敏感性和特异性分别为 83%和 81%。IR 在健康成年伊拉克人中的患病率为 28.92%。TG/HDL-c 比值对 IR 具有很好的预测价值。
