Brody J P, Krause J R
Leuk Res. 1986;10(5):475-80. doi: 10.1016/0145-2126(86)90082-2.
Morphometric analysis of megakaryocyte cellular and nuclear size in bone marrow biopsies of 28 cases of acute non-lymphocytic leukemia at diagnosis and 15 controls was performed. Median megakaryocyte cell diameter, median area, and perimeter were less than 95% control range (less than 18.5 microns, less than 263 microns2, less than 64 microns) in 5/5 of induction failures. Attainment of complete remission was significantly greater in those with median megakaryocyte diameter greater than or equal to 18.5 microns (p less than 0.01), median area greater than or equal to 263 microns (p less than 0.001) and perimeter greater than or equal to 64 microns (p less than 0.001). Prolonged complete remission was correlated with normal megakaryocyte size with the median megakaryocyte area, median diameter, and perimeter within or greater than the reference range (greater than or equal to 18.5 microns, greater than or equal to 263 microns2, greater than or equal to 64 microns, p less than 0.05) in 6/7 cases with continuous remissions greater than 3 yr. Measurements of megakaryocyte size may be useful in predicting induction failure and possibly the likelihood of prolonged complete remission in adults.
对28例急性非淋巴细胞白血病患者诊断时的骨髓活检以及15例对照者的巨核细胞的细胞和细胞核大小进行了形态测量分析。在5例诱导失败的患者中，巨核细胞的中位细胞直径、中位面积和周长均低于对照范围的95%（小于18.5微米、小于263平方微米、小于64微米）。中位巨核细胞直径大于或等于18.5微米（p<0.01）、中位面积大于或等于263平方微米（p<0.001）以及周长大于或等于64微米（p<0.001）的患者完全缓解率显著更高。在7例持续缓解超过3年的患者中，有6例的长期完全缓解与正常巨核细胞大小相关，其巨核细胞的中位面积、中位直径和周长在参考范围内或大于参考范围（大于或等于18.5微米、大于或等于263平方微米、大于或等于64微米，p<0.05）。测量巨核细胞大小可能有助于预测成人诱导失败以及长期完全缓解的可能性。
