Bremme K, Eneroth P, Nordström L, Nilsson B
Magnesium. 1986;5(2):85-94.
Seventeen third trimester pregnant women received a 30-min intravenous infusion of terbutaline 20 micrograms/min. The drug caused a prompt (30 min) drop in serum potassium (p less than 0.001) and a decrease after 120 min in serum magnesium concentrations (p less than 0.002). No significant changes in calcium or sodium levels were observed. The altered serum magnesium concentrations were significantly (p less than 0.05) correlated to increases in plasma free fatty acid levels but not to elevated plasma glucose concentrations. Whatever the mechanism for the lowering of serum magnesium may be, the potential danger of administering a beta-adrenoceptor agonist to pregnant women with low serum potassium and magnesium levels is underlined.
17名孕晚期孕妇接受了每分钟20微克特布他林的30分钟静脉输注。该药物导致血清钾迅速（30分钟）下降（p<0.001），120分钟后血清镁浓度降低（p<0.002）。未观察到钙或钠水平有显著变化。血清镁浓度的改变与血浆游离脂肪酸水平的升高显著相关（p<0.05），但与血浆葡萄糖浓度升高无关。无论血清镁降低的机制如何，强调了对血清钾和镁水平低的孕妇使用β-肾上腺素能受体激动剂的潜在危险。
