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Phase II study: the combination DTIC, BCNU, actinomycin D, and vincristine in disseminated malignant melanoma.

作者信息

Creagan E T, Schutt A J, Long H J, Green S J

出版信息

Med Pediatr Oncol. 1986;14(2):86-7. doi: 10.1002/mpo.2950140206.

DOI:10.1002/mpo.2950140206
PMID:3713642
Abstract

Thirty patients with disseminated malignant melanoma received the combination DTIC, BCNU, actinomycin D, and vincristine. The objective response rate was 17 percent concomitant with moderate-to-severe nausea and vomiting in 80 percent of patients. Hematologic toxicity was transient. In the dose and schedule that we used, the four-drug regimen does not offer meaningful benefit for patients with advanced melanoma.

摘要

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