Taniura M
Nihon Geka Gakkai Zasshi. 1986 Apr;87(4):423-34.
The effect of splenectomy on hepatic regeneration after partial hepatectomy was investigated in splenectomized and non-splenectomized rats. The results were as follows: The liver weight per body weight after partial hepatectomy increased significantly at 2 and 4 days in splenectomized group compared with non-splenectomized one. The rates of 3H-thymidine uptake in the regenerating liver cells at 24 hours after partial hepatectomy were more enhanced in splenectomized group than in non-splenectomized one. Thymidine kinase activity of the regenerating liver at 24 hours after partial hepatectomy in splenectomized rats was significantly higher than those in non-splenectomized rats. Both mitotic indices and labeling indices at 24 hours after partial hepatectomy in splenectomized rats were significantly higher than those in non-splenectomized group. The cells of mitotic stage were distributed mainly periportal area. From those results, it is suggested that the spleen has some inhibitory factors on hepatic regeneration after partial hepatectomy.
在脾切除和未脾切除的大鼠中研究了脾切除对部分肝切除术后肝再生的影响。结果如下：与未脾切除组相比，脾切除组在部分肝切除术后第2天和第4天，肝脏重量与体重之比显著增加。部分肝切除术后24小时，脾切除组再生肝细胞中3H-胸腺嘧啶核苷摄取率比未脾切除组更高。脾切除大鼠在部分肝切除术后24小时再生肝脏的胸苷激酶活性显著高于未脾切除大鼠。脾切除大鼠在部分肝切除术后24小时的有丝分裂指数和标记指数均显著高于未脾切除组。有丝分裂期细胞主要分布在门静脉周围区域。从这些结果来看，提示脾脏对部分肝切除术后的肝再生具有某些抑制因子。
