Michalska J
Mutat Res. 1986 Jun;170(3):119-23. doi: 10.1016/0165-1218(86)90024-8.
The induction of chromosomal aberrations by 5 derivatives of nitro-9-aminoacridine in V79 Chinese hamster cells was observed. The clastogenic activity of the compounds tested depended on the position of the NO2 group in the acridine ring. The strongest clastogens were derivatives with NO2 in position 1. The remaining derivatives placed in decreasing order of clastogenic activity were: 3-nitro, 4-nitro and 2-nitro. In addition, 2-nitro and 3-nitro derivatives produced hyperdiploid/polyploid metaphases.
观察了5种硝基-9-氨基吖啶衍生物对V79中国仓鼠细胞染色体畸变的诱导作用。所测试化合物的致断裂活性取决于吖啶环中NO2基团的位置。致断裂活性最强的是1位含NO2的衍生物。其余衍生物按致断裂活性由高到低的顺序为：3-硝基、4-硝基和2-硝基。此外，2-硝基和3-硝基衍生物产生超二倍体/多倍体中期。
