Nagata Mitsuru
Department of Endoscopy, Shonan Fujisawa Tokushukai Hospital, Fujisawa 251-0041, Kanagawa, Japan.
World J Gastrointest Endosc. 2023 Apr 16;15(4):265-272. doi: 10.4253/wjge.v15.i4.265.
Endoscopic submucosal dissection (ESD) procedure has a longer procedure time and higher perforation rate than endoscopic mucosal resection owing to technical complications, including a poor field of vision and inadequate tension for the submucosal dissection plane. Various traction devices were developed to secure the visual field and provide adequate tension for the dissection plane. Two randomized controlled trials demonstrated that traction devices reduce colorectal ESD procedure time compared with conventional ESD (C-ESD), but they had limitations, including a single-center fashion. The CONNECT-C trial was the first multicenter randomized controlled trial comparing the C-ESD and traction device-assisted ESD (T-ESD) for colorectal tumors. In the T-ESD, one of the device-assisted traction methods (S-O clip, clip-with-line, and clip pulley) was chosen according to the operator's discretion. The median ESD procedure time (primary endpoint) was not significantly different between C-ESD and T-ESD. For lesions ≥ 30 mm in diameter or in cases treated by nonexpert operators, the median ESD procedure time tended to be shorter in T-ESD than in C-ESD. Although T-ESD did not reduce ESD procedure time, the CONNECT-C trial results suggest that T-ESD is effective for larger lesions and nonexpert operators in colorectal ESD. Compared with esophageal and gastric ESD, colorectal ESD has some difficulties, including poor endoscope maneuverability, which may be associated with prolonged ESD procedure time. T-ESD may not effectively improve these issues, but a balloon-assisted endoscope and underwater ESD may be promising options and these methods can be combined with T-ESD.
由于技术并发症,包括视野不佳和黏膜下剥离平面张力不足,内镜黏膜下剥离术(ESD)的手术时间比内镜黏膜切除术更长,穿孔率更高。为了确保视野并为剥离平面提供足够的张力,人们开发了各种牵引装置。两项随机对照试验表明,与传统ESD(C-ESD)相比,牵引装置可缩短结直肠ESD的手术时间,但它们存在局限性,包括单中心模式。CONNECT-C试验是第一项比较C-ESD和牵引装置辅助ESD(T-ESD)治疗结直肠肿瘤的多中心随机对照试验。在T-ESD中,根据操作者的判断选择一种装置辅助牵引方法(S-O夹、带线夹和夹式滑轮)。C-ESD和T-ESD之间的ESD手术时间中位数(主要终点)没有显著差异。对于直径≥30mm的病变或由非专业操作者治疗的病例,T-ESD的ESD手术时间中位数往往比C-ESD短。虽然T-ESD没有缩短ESD手术时间,但CONNECT-C试验结果表明,T-ESD对结直肠ESD中的较大病变和非专业操作者有效。与食管和胃ESD相比,结直肠ESD存在一些困难,包括内镜操作灵活性差,这可能与ESD手术时间延长有关。T-ESD可能无法有效改善这些问题,但球囊辅助内镜和水下ESD可能是有前景的选择,并且这些方法可以与T-ESD联合使用。