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橡皮筋牵引辅助内镜黏膜下剥离术治疗食管癌前病变的应用效果

The application effect of rubber band traction assisted endoscopic submucosal dissection for esophageal precancerous lesions.

作者信息

Zhang Wenjuan, Ding Shi, Zhao Xuerong, Li Changjuan, Liu Haitao, Ma Lidong

机构信息

Wenjuan Zhang, Department of Gastroenterology, Handan First Hospital, Handan, Hebei Province 056000, P.R. China.

Shi Ding, Department of Pharmacology, Chengde Medical University, Chengde, Hebei Province 067000, P.R. China.

出版信息

Pak J Med Sci. 2025 Jun;41(6):1683-1688. doi: 10.12669/pjms.41.6.12168.

Abstract

OBJECTIVE

This study aimed to evaluate the efficacy of rubber band traction-assisted ESD (RBT-ESD) in treating esophageal precancerous lesions (EPLs).

METHODS

This retrospective cohort study included the clinical data of 110 patients with EPLs who received ESD from June 1, 2022 to November 10, 2024 at the Handan First Hospital. Of them, 55 patients who underwent RBT-ESD were matched with patients who underwent conventional ESD (C-ESD) using propensity score matching in a 1:1 ratio. Surgical outcomes, one-time complete resection rate, quality of life (QOL), and incidence of complications were compared between the two groups.

RESULTS

RBT-ESD was associated with considerably lower surgical time, intraoperative mucosal injection volume, submucosal dissection time, mucosal dissection speed, and postoperative hospital stay than C-ESD (<0.05). The one-time complete resection rate of the RBT-ESD group (100%) was higher than that of the C-ESD group (94.5%), but the difference was not significant (>0.05). Post-surgery QLQ-C30 scores in both groups increased and were significantly higher in the RBT-ESD group compared to the C-ESD group (<0.05). The incidence of adverse events was comparable in the two groups (>0.05).

CONCLUSIONS

Compared with C-ESD, RBT-ESD for EPLs may optimize the effectiveness of the surgical treatment and enhance patients' QOL with comparable safety.

摘要

目的

本研究旨在评估橡皮筋牵引辅助内镜黏膜下剥离术(RBT-ESD)治疗食管癌前病变(EPLs)的疗效。

方法

这项回顾性队列研究纳入了2022年6月1日至2024年11月10日在邯郸市第一医院接受ESD治疗的110例EPLs患者的临床资料。其中,55例行RBT-ESD的患者与接受传统ESD(C-ESD)的患者采用倾向评分匹配法按1:1比例进行匹配。比较两组的手术结果、一次性完全切除率、生活质量(QOL)和并发症发生率。

结果

与C-ESD相比,RBT-ESD的手术时间、术中黏膜注射量、黏膜下剥离时间、黏膜剥离速度和术后住院时间均显著缩短(<0.05)。RBT-ESD组的一次性完全切除率(100%)高于C-ESD组(94.5%),但差异无统计学意义(>0.05)。两组术后QLQ-C30评分均升高,且RBT-ESD组显著高于C-ESD组(<0.05)。两组不良事件发生率相当(>0.05)。

结论

与C-ESD相比,RBT-ESD治疗EPLs可能优化手术治疗效果,并在安全性相当的情况下提高患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e43/12223726/1159691ba6d0/PJMS-41-1683-g001.jpg

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