Poku K
Am J Epidemiol. 1979 Feb;109(2):226-35. doi: 10.1093/oxfordjournals.aje.a112677.
Infectious transmission of streptococci in families has been demonstrated to follow Greenwood's chain-binomial model in its simplest form which did not need beta transformation to correct for differences in susceptibility between families. Following the application of this model, an estimate of the risk of acquisition of M-typable group A beta-hemolytic streptococci is given (p = 0.05--0.06). The risk is the same among siblings of rheumatic fever patients and children from non-rheumatic families. This emphasizes that the familial aggregation associated with rheumatic fever is not due to increased susceptibility of such families to streptococcal infections.
家庭中链球菌的传染性传播已被证明遵循格林伍德链二项式模型的最简单形式，该形式无需进行β转换来校正家庭间易感性的差异。应用该模型后，给出了获得M型A组β溶血性链球菌风险的估计值（p = 0.05 - 0.06）。风湿热患者的兄弟姐妹与非风湿热家庭的儿童获得感染的风险相同。这强调了与风湿热相关的家族聚集现象并非由于此类家庭对链球菌感染的易感性增加所致。
