Edelstein A D, Miller A, Zimelman A P, Rocklin R E, Neiman R S
Am J Hematol. 1978;5(1):55-62. doi: 10.1002/ajh.2830050108.
A patient presented with lymphopenia, anergy, hypogammaglobulinemia and hypersplenism. Histologic examination of the spleen and lymph node revealed noncaseating sarcoid-like granulomas. Despite a significant rise in circulating lymphocytes after splenectomy there was in vivo and in vitro evidence of B- and T-lymphocyte dysfunction. A histologic picture mimicking sarcoidosis may occur in patients with immune deficiency. The granulomatous proliferation may represent an altered host response to antigen.
一名患者出现淋巴细胞减少、无反应性、低丙种球蛋白血症和脾功能亢进。脾脏和淋巴结的组织学检查显示非干酪样结节病样肉芽肿。尽管脾切除术后循环淋巴细胞显著增加，但体内和体外均有B淋巴细胞和T淋巴细胞功能障碍的证据。免疫缺陷患者可能出现类似结节病的组织学表现。肉芽肿性增殖可能代表宿主对抗原的反应改变。
