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: 一种罕见病原体引起的微孢子虫性基质性角膜炎的分子特征。

: molecular characterization of a rare pathogen causing microsporidial stromal keratitis.

机构信息

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, Telangana, 500034, India.

Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute, Hyderabad, India.

出版信息

Future Microbiol. 2023 Mar;18:249-253. doi: 10.2217/fmb-2022-0082. Epub 2023 May 4.

Abstract

The authors report the clinical and microbiological findings of a unique case of stromal keratitis caused by a rare microsporidium, . This case of stromal keratitis was in a 49-year-old male with a history of COVID-19 infection and diabetes mellitus. Corneal scraping specimens revealed numerous microsporidia spores upon microscopic examination. PCR of the corneal button revealed the presence of infection, which could be controlled by penetrating keratoplasty surgery. The graft was clear with no recurrence of infection until the last follow-up 6 weeks postsurgery. This is the first case of human stromal keratitis caused by this organism in a post-COVID infection, confirmed by molecular diagnosis.

摘要

作者报告了一例由罕见的微孢子虫引起的基质角膜炎的临床和微生物学发现。这例基质角膜炎发生于一名 49 岁男性,有 COVID-19 感染和糖尿病病史。角膜刮片标本在显微镜下发现大量微孢子虫孢子。角膜活检标本的 PCR 显示存在感染,穿透性角膜移植术可控制感染。移植物在最后一次随访 6 周后仍保持清晰,无感染复发。这是首例 COVID 感染后由该病原体引起的人类基质角膜炎,通过分子诊断得到证实。

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