Pradhan Sayali, Mascarenhas Jeena, Srinivasan M
Aravind Eye Hospital, Madurai, India.
Cornea. 2015 Mar;34(3):353-4. doi: 10.1097/ICO.0000000000000337.
To describe the clinical features, disease course, management, and visual outcome of stromal microsporidial keratitis involving the corneal graft in an immunocompetent patient.
Case report.
We report the case of a 21-year-old immunocompetent woman, who underwent penetrating keratoplasty for advanced keratoconus in her right eye and presented with features of acute graft rejection after 15 months. Standard treatment using topical and systemic steroids failed to reverse the graft rejection. A regraft was performed in that eye. Histopathology of the donor corneal button revealed microsporidiosis involving the deep stroma.
Microsporidiosis is rarely encountered in a corneal graft and masquerades as acute graft rejection. Histopathology could help in making a final diagnosis.
描述免疫功能正常患者中累及角膜移植片的基质性微孢子虫角膜炎的临床特征、病程、治疗及视力预后。
病例报告。
我们报告一例21岁免疫功能正常女性患者，其右眼因晚期圆锥角膜接受穿透性角膜移植术，术后15个月出现急性移植排斥反应特征。使用局部和全身类固醇的标准治疗未能逆转移植排斥反应。该眼进行了再次移植。供体角膜植片的组织病理学检查显示深部基质存在微孢子虫病。
微孢子虫病在角膜移植中很少见，且易伪装为急性移植排斥反应。组织病理学有助于做出最终诊断。
