Enhancing the antischistosomal activity of carvacryl acetate using nanoemulsion.

To formulate a carvacryl acetate nanoemulsion (CANE) and test its antischistosomal activity. CANE was prepared and tested on adult worms and both human and animal cell lines. Next, CANE was administered orally to mice infected with either a prepatent infection or a patent infection of . CANE was stable during 90 days of analysis. CANE showed anthelmintic activity, and no cytotoxic effects were observed. , CANE was more effective than the free compounds in reducing worm burden and egg production. Treatment with CANE was more effective for prepatent infections than praziquantel. CANE improves antiparasitic properties and may be a promising delivery system for schistosomiasis treatment.