de Souza Rafael L, Mengarda Ana C, Roquini Daniel B, Melo Camila O, de Morais Mayara C, C Espírito-Santo Maria Cristina, de Sousa Damião P, Moraes Josué de, Oliveira Elquio E
Laboratory of Synthesis & Drug Delivery, State University of Paraíba, João Pessoa, 58071-160, Brazil.
Research Center for Neglected Diseases, Guarulhos University, Guarulhos, 07023-070, Brazil.
Nanomedicine (Lond). 2023 Feb;18(4):331-342. doi: 10.2217/nnm-2022-0228. Epub 2023 May 4.
To formulate a carvacryl acetate nanoemulsion (CANE) and test its antischistosomal activity. CANE was prepared and tested on adult worms and both human and animal cell lines. Next, CANE was administered orally to mice infected with either a prepatent infection or a patent infection of . CANE was stable during 90 days of analysis. CANE showed anthelmintic activity, and no cytotoxic effects were observed. , CANE was more effective than the free compounds in reducing worm burden and egg production. Treatment with CANE was more effective for prepatent infections than praziquantel. CANE improves antiparasitic properties and may be a promising delivery system for schistosomiasis treatment.
制备乙酸香芹酯纳米乳剂（CANE）并测试其抗血吸虫活性。制备CANE并在成虫以及人和动物细胞系上进行测试。接下来，将CANE口服给予感染了潜伏期感染或显性感染的小鼠。在90天的分析期内CANE保持稳定。CANE显示出驱虫活性，且未观察到细胞毒性作用。此外，在减轻虫负荷和减少产卵方面，CANE比游离化合物更有效。对于潜伏期感染，CANE治疗比吡喹酮更有效。CANE改善了抗寄生虫特性，可能是一种有前景的血吸虫病治疗递送系统。
