Rheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Int J Rheum Dis. 2023 Jun;26(6):1103-1110. doi: 10.1111/1756-185X.14705. Epub 2023 May 5.
To assess the validity of Behçet's Syndrome Overall Damage Index (BODI) and Behçet's Disease Damage Index (BDI) as tools for the detection of damage accrual in Behçet's patients compared to Vasculitis Damage Index (VDI). Also, to evaluate the correlation and the interclass correlation among the 3 indices to find out their consistency.
A prospective cohort study was carried out on 102 adult Behçet's disease (BD) patients who were diagnosed according to the International Study Group criteria for BD. Disease severity and organ damage were assessed for each patient by VDI, BDI and BODI at baseline and 1-year follow-up visits. Damage accrual for each index was defined when there was an increase of at least 1 point (∆ ≥ 1) among the baseline and the follow-up visits.
Correlations among the 3 indices were significant, with (r = 0.835, P < 0.001) between VDI and BODI, (r = 0.835, P < 0.001) between VDI and BDI, and (r = 0.844, P < 0.001) between BODI and BDI scores. A highly significant positive correlation existed between the 3 indices and age and disease duration. In contrast, the correlation with the BD Current Activity Form was non-significant, which indicates good discriminative validity of the 3 indices. Neuropsychiatric and ocular systems showed a strong interclass correlation among the 3 indices. Regarding detecting damage accrual, BDI was more sensitive than BODI and showed more agreement with VDI.
BD damage indices, VDI, BODI and BDI, had good convergent and discriminative validity for the assessment of BD damage. BDI had more sensitivity than BODI to the detection of damage accrual.
评估贝赫切特综合征整体损伤指数（BODI）和贝赫切特病损伤指数（BDI）与血管炎损伤指数（VDI）相比作为检测贝赫切特患者损伤累积的工具的有效性。此外，评估这 3 种指数之间的相关性和组内相关性，以确定它们的一致性。
对 102 例符合国际贝赫切特病研究组标准的成人贝赫切特病（BD）患者进行前瞻性队列研究。在基线和 1 年随访时，通过 VDI、BDI 和 BODI 评估每位患者的疾病严重程度和器官损伤。当基线和随访之间至少增加 1 分（∆≥1）时，定义为每个指数的损伤累积。
3 种指数之间的相关性显著，VDI 与 BODI 之间（r=0.835，P<0.001）、VDI 与 BDI 之间（r=0.835，P<0.001）、BODI 与 BDI 之间（r=0.844，P<0.001）。3 种指数与年龄和疾病持续时间之间存在高度显著的正相关。相反，与 BD 当前活动表的相关性无统计学意义，表明 3 种指数具有良好的鉴别效度。神经精神和眼部系统在 3 种指数之间具有很强的组内相关性。在检测损伤累积方面，BDI 比 BODI 更敏感，与 VDI 的一致性更高。
BD 损伤指数，VDI、BODI 和 BDI，对评估 BD 损伤具有良好的收敛性和鉴别效度。BDI 在检测损伤累积方面比 BODI 更敏感。
