Al Mudhaffar A, Hübler D, Schilling G, Chemnitius K H
Pharmazie. 1986 Mar;41(3):199-201.
A comparative study was made of the closed-chest cardiovascular effects of Cordemcura (amrinone), isoprenaline, and dobutamine in anaesthetized cats (n = 17). The haemodynamic parameters used for this purpose include: maximum rate of both left ventricular pressure rise (dp/dtmax) and decline (dp/dtmin), heart frequency (HFR), arterial blood pressure, both systolic (Ps) and diastolic (Pd). The maximum changes of the haemodynamic parameters after increasing iv. bolus injections of the test substances were used to plot the dose-effect curves of the single parameters for each substance. All the 3 pharmaceuticals caused dp/dtmax to rise, with quantitative differences being found. Moreover, quantitatively different positive chronotropic effects have been found. The influence on the remaining haemodynamic parameters was different both in the quantitative and in the qualitative sense. The results were discussed with regard to comparing the cardiovascular effects of Cordemcura with isoprenaline and dobutamine.
对17只麻醉猫进行了一项比较研究，观察氨力农（强心胺）、异丙肾上腺素和多巴酚丁胺对闭胸心血管系统的影响。用于此目的的血流动力学参数包括：左心室压力上升（dp/dtmax）和下降（dp/dtmin）的最大速率、心率（HFR）、动脉血压，包括收缩压（Ps）和舒张压（Pd）。静脉注射受试物质大剂量后血流动力学参数的最大变化用于绘制每种物质单个参数的剂量-效应曲线。所有这三种药物均使dp/dtmax升高，且存在量的差异。此外，还发现了量的不同的正性变时效应。对其余血流动力学参数的影响在量和质两方面均有所不同。结合比较氨力农与异丙肾上腺素和多巴酚丁胺对心血管系统的影响对结果进行了讨论。
