Gali Jayasri Helen, Shah Chirali, Keerthi B Y, Thomas Vimala
Department of Pulmonary Medicine, Telangana Institute of Medical Sciences and Research, Gachibowli, Hyderabad, Telangana, India.
Department of General Medicine, Telangana Institute of Medical Sciences and Research, Gachibowli, Hyderabad, Telangana, India.
Lung India. 2023 May-Jun;40(3):215-221. doi: 10.4103/lungindia.lungindia_28_22.
To evaluate the demographic profile, clinical severity, and outcome of Covid-19 infection in hospitalised vaccinated individuals.
An observational, cross-sectional study was conducted among Covid-19 infected hospitalised patients. Clinicodemographic profile, severity, and outcome of Covid-19 infection among the vaccinated group (VG) were recorded. These patients were also compared with unvaccinated group (UVG) with Covid-19 infection admitted during the study period. Cox proportional hazards models was used to estimate hazard ratios for mortality risk in both groups.
Out of 580 participants, 48.2% were vaccinated with either one (71%) or two doses (28.9%). In both, VG and UVG, majority 55.8% belonged to 51-75 years. Males were predominant with 62.9% in both VG and UVGs. Day of illness at admission from symptom onset (DOI), progression of disease, ICU stay, oxygen requirement, mortality was significantly higher in UVG than in VG (p < 0.05). Steroid duration (p < 0.001) and anti-coagulation time (p < 0.001) were significantly higher in UVG than in VG. D dimer levels were significantly higher in UVG than in VG (p < 0.05). Increased age, (p < 0.0004), severity of disease, (p < 0.0052), increased oxygen requirement (p < 0.001), elevated C-reactive protein levels (Moderate: P < 0.0013; Severe P < 0.0082), and elevated IL-6 levels (p < 0.001) were the significant determinants of Covid-19-related mortality in both VG and UVGs.
Vaccinated individuals have shown milder severity, had reduced hospital stay and better outcomes as compared to unvaccinated individuals suggesting a potential vaccine efficacy against Covid-19.
评估住院接种疫苗个体的新冠病毒感染的人口统计学特征、临床严重程度及预后。
对新冠病毒感染住院患者进行一项观察性横断面研究。记录接种疫苗组（VG）中新冠病毒感染的临床人口统计学特征、严重程度及预后。还将这些患者与研究期间收治的未接种疫苗的新冠病毒感染组（UVG）进行比较。采用Cox比例风险模型估计两组的死亡风险比。
在580名参与者中，48.2%接种了一剂（71%）或两剂（28.9%）疫苗。在VG和UVG中，大多数（55.8%）年龄在51 - 75岁。男性占主导，在VG和UVG中均为62.9%。UVG的入院时症状出现后的患病天数（DOI）、疾病进展、ICU住院时间、氧气需求、死亡率均显著高于VG（p < 0.05）。UVG的类固醇使用时长（p < 0.001）和抗凝时间（p < 0.001）显著高于VG。UVG的D - 二聚体水平显著高于VG（p < 0.05）。年龄增加（p < 0.0004）、疾病严重程度增加（p < 0.0052）、氧气需求增加（p < 0.001）、C反应蛋白水平升高（中度：P < 0.0013；重度P < 0.0082）以及白细胞介素 - 6水平升高（p < 0.001）是VG和UVG中新冠病毒相关死亡的显著决定因素。
与未接种疫苗的个体相比，接种疫苗的个体表现出较轻的严重程度、缩短的住院时间和更好的预后，提示疫苗对新冠病毒具有潜在的疗效。
