Herman J P, Thomas G J, Laycock J F, Gartside I B, Gash D M
Physiol Behav. 1986;36(4):713-21. doi: 10.1016/0031-9384(86)90359-8.
Samples of genetically diabetes insipidus (DI) and normal (NO) rats were obtained from American suppliers (Rochester (RO)/DI and NO) and from the colony maintained at Charing Cross Hospital in London (Charing Cross (CC)/DI and NO) to test the hypothesis that the behavior of vasopressin-deficient Brattleboro (DI) and possibly normal Long-Evans rats may vary significantly between different colonies. DI rats of both colonies exhibit longer latencies to emerge into an open field than do NO rats. RO/DI and CC/DI rats acquire goal-approach behavior in a straight runway at similar rates. Following shock in the runway goal box, however, RO/DI rats exhibit marked recovery of running behavior relative to CC/DI rats over the ten post-shock sessions. All DI animals show reductions in goal-approach speed on the first post-shock trial, indicating that the aversive experience is remembered. CC/NO rats acquire goal-approach behavior more slowly than RO/NO rats, but neither NO group shows substantial recovery of goal approach behavior following shock. CC/DI rats showed impaired acquisition of a delayed non-match to sample task relative to RO/DI rats. All groups demonstrated the ability to utilize representational memory to solve the delayed non-match to sample problem once the contingency was learned. The results indicate that DI and normal Long-Evans rats from different colonies show marked differences in behavior. Since differences between DI and normal rats on tests indicating memory are not consistent across colonies, it is unlikely that vasopressin deficit is solely responsible for memory deficiencies. However, vasopressin deficiency may result in changes in temperament.
从美国供应商处（罗切斯特（RO）/遗传性尿崩症（DI）和正常（NO）大鼠）以及伦敦查令十字医院饲养的大鼠群体中获取遗传性尿崩症（DI）和正常（NO）大鼠样本，以检验以下假设：血管加压素缺乏的布拉特洛维（DI）大鼠以及可能正常的长 Evans 大鼠在不同群体之间的行为可能存在显著差异。两个群体的 DI 大鼠进入旷场的潜伏期都比 NO 大鼠长。RO/DI 和 CC/DI 大鼠在直线跑道上获得趋近目标行为的速度相似。然而，在跑道目标箱受到电击后，在电击后的十次实验中，RO/DI 大鼠相对于 CC/DI 大鼠表现出明显的奔跑行为恢复。所有 DI 动物在电击后的第一次实验中趋近目标的速度都有所降低，这表明厌恶经历被记住了。CC/NO 大鼠比 RO/NO 大鼠获得趋近目标行为的速度更慢，但两个 NO 组在电击后都没有表现出趋近目标行为的显著恢复。相对于 RO/DI 大鼠，CC/DI 大鼠在延迟非匹配样本任务的习得方面受损。一旦学会了这种关联性，所有组都表现出利用表象记忆解决延迟非匹配样本问题的能力。结果表明，来自不同群体的 DI 和正常长 Evans 大鼠在行为上存在显著差异。由于在表明记忆的测试中，DI 大鼠和正常大鼠之间的差异在不同群体中并不一致，所以血管加压素缺乏不太可能是记忆缺陷的唯一原因。然而，血管加压素缺乏可能导致气质变化。
