Torii K, Mimura T, Takasaki Y, Ichimura M
Physiol Behav. 1986;36(4):765-71. doi: 10.1016/0031-9384(86)90366-5.
Aspartame (APM; L-aspartyl-L-phenylalanine methyl ester), was investigated for its ability to alter levels of the large neutral amino acids and monoamines in overnight fasted rats allowed to consume meals with or without protein for two hours. Additionally, the possible long term behavioral consequences of APM in 25% casein diets with or without 10% sucrose were determined. Acute APM ingestion increased both plasma and brain phenylalanine and tyrosine levels, but brain tryptophan levels were not altered regardless of dietary protein. Brain norepinephrine and dopamine levels were unaltered by any of the diet while serotonin levels were slightly increased when a protein-free diet was consumed. But APM and/or protein ingestion minimized this increase of brain serotonin levels as much as controls. Chronic APM ingestion failed to influence diurnal feeding patterns, meal size distributions, or diurnal patterns of spontaneous motor activity. The chronic ingestion of abuse doses of APM produced no significant chemical changes in brain capable of altering behavioral parameters believed to be controlled by monoamines in rats.
研究了阿斯巴甜（APM；L-天冬氨酰-L-苯丙氨酸甲酯）对禁食过夜的大鼠在进食含或不含蛋白质的餐食两小时后，其体内大中性氨基酸和单胺水平的影响。此外，还测定了在含或不含10%蔗糖的25%酪蛋白饮食中，APM可能产生的长期行为后果。急性摄入APM会增加血浆和脑内苯丙氨酸及酪氨酸水平，但无论饮食中是否含蛋白质，脑内色氨酸水平均未改变。任何一种饮食对脑内去甲肾上腺素和多巴胺水平均无影响，而在食用无蛋白饮食时，血清素水平略有升高。但APM和/或蛋白质摄入可使脑内血清素水平的升高尽可能降至与对照组相同的程度。长期摄入APM未能影响昼夜进食模式、餐量分布或自发运动活动的昼夜模式。长期摄入滥用剂量的APM并未在大鼠脑内产生能够改变被认为由单胺控制的行为参数的显著化学变化。
