Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raibareli Road, Lucknow 226025, India.
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Raibareli Road, Lucknow 226025, India; Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Lucknow, Lucknow 226031, Uttar Pradesh, India.
Int Immunopharmacol. 2023 Jun;119:110236. doi: 10.1016/j.intimp.2023.110236. Epub 2023 May 5.
Colorectal cancer (CRC) is currently recognized as the third most prevalent cancer worldwide. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine. It has been found effective in ameliorating the growth and progression of cancerous cells. However, its pharmacological effect on colon damage remains elusive. Hence, in this study, we have shown the role of vinpocetine in DMH-induced colon carcinogenesis. At first, male albino Wistar rats were administered with DMH consistently for four weeks to induce pre-neoplastic colon damage. Afterward, animals were treated with vinpocetine (4.2 and 8.4 mg/kg/day p.o.) for 15 days. Serum samples were collected to assess the physiological parameters, including ELISA and NMR metabolomics. Colon from all the groups was collected and processed separately for histopathology and western blot analysis. Vinpocetine attenuated the altered plasma parameters; lipid profile and showed anti-proliferative action as evidenced by suppressed COX-2 stimulation and decreased levels of IL-1β, IL-2, IL-6, and IL-10. Vinpocetine is significantly effective in preventing CRC which may be associated with its anti-inflammatory and antioxidant potential. Accordingly, vinpocetine could serve as a potential anticancer agent for CRC treatment and thus be considered for future clinical and therapeutic research.
结直肠癌（CRC）目前被认为是全球第三大常见癌症。长春西汀是长春碱类长春胺的合成衍生物。已发现其在改善癌细胞的生长和进展方面有效。然而，其对结肠损伤的药理作用仍不清楚。因此，在这项研究中，我们展示了长春西汀在 DMH 诱导的结肠癌发生中的作用。首先，雄性白化 Wistar 大鼠连续四周给予 DMH，以诱导前肿瘤性结肠损伤。然后，动物用长春西汀（4.2 和 8.4 mg/kg/天 p.o.）治疗 15 天。收集血清样本以评估生理参数，包括 ELISA 和 NMR 代谢组学。收集所有组的结肠并分别进行组织病理学和 Western blot 分析。长春西汀减轻了改变的血浆参数；脂质谱，并表现出抗增殖作用，这可通过抑制 COX-2 刺激和降低 IL-1β、IL-2、IL-6 和 IL-10 的水平来证明。长春西汀在预防 CRC 方面非常有效，这可能与其抗炎和抗氧化潜力有关。因此，长春西汀可以作为 CRC 治疗的潜在抗癌药物，因此可以考虑用于未来的临床和治疗研究。
