Department of Occupational and Environmental Health, School of Public Health, Zunyi Medical University, Zunyi 563000, China.
Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
Sci Total Environ. 2023 Aug 10;885:163949. doi: 10.1016/j.scitotenv.2023.163949. Epub 2023 May 4.
Association linking polycyclic aromatic hydrocarbons (PAHs) to blood coagulation function during pregnancy remains absent. Hence, we conducted a cross-sectional study including 679 late pregnant women (27.2 ± 5.1 years old) drawn from Zunyi birth cohort, Southwest China. During late pregnancy, ten urinary PAHs metabolites and four clinical blood coagulation parameters were measured, including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and fibrinogen (FIB). Multiple linear regression, Restricted cubic spline (RCS) regression, Bayesian kernel machine regression (BKMR), and quantile g-computation (Q-g) regression were used to investigate their single, nonlinear, and mixed associations. Each 2.7-fold increment in 2-hydroxyfluorene (2-OHFlu), 9-hydroxyfluorene (9-OHFlu), 1-hydroxyphenanthrene (1-OHPhe), 2-hydroxyphenanthrene (2-OHPhe), and 3-hydroxyphenanthrene (3-OHPhe) were associated with 0.287 s, 0.190 s, 0.487 s, and 0.396 s shorter APTT, respectively; each 2.7-fold increment in 2-OHPhe was associated with a 0.047 s longer PT; each 2.7-fold increment in 9-hydroxyphenanthrene (9-OHPhe) and 1-hydroxypyrene (1-OHPyr) were associated with 0.087 s and 0.031 s shorter TT, respectively; and each 2.7-fold increment in 1-hydroxynaphthalene (1-OHNap) was associated with 0.032 g/L higher FIB level. The nonlinear association of 2-OHPhe with APTT and 1-OHNap with FIB were also observed. Furthermore, the shortened APTT and TT associated with PAHs mixture were indicated by BKMR and Q-g model. BKMR also revealed a nonlinear association of 2-OHPhe with PT and an interaction effect of 2-OHPhe and 3-OHPhe on APTT. Our results indicate that urinary PAHs was associated with shortened coagulation time and increased FIB. Therefore, more attention should be paid for late pregnant women to prevent PAHs-associated risk of thrombosis. Future perspective studies to confirm our findings and explore the underlying biological mechanism are warranted.
怀孕期间多环芳烃（PAHs）与血液凝固功能之间的关联尚不清楚。因此，我们进行了一项横断面研究，纳入了来自中国西南部遵义出生队列的 679 名晚期孕妇（27.2±5.1 岁）。在晚期妊娠期间，测量了 10 种尿中 PAHs 代谢物和 4 种临床凝血参数，包括活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）和纤维蛋白原（FIB）。采用多元线性回归、受限立方样条（RCS）回归、贝叶斯核机器回归（BKMR）和分位数 g 计算（Q-g）回归来研究它们的单一、非线性和混合关联。2-羟基芴（2-OHFlu）、9-羟基芴（9-OHFlu）、1-羟基菲（1-OHPhe）、2-羟基菲（2-OHPhe）和 3-羟基菲（3-OHPhe）每增加 2.7 倍，APTT 分别缩短 0.287s、0.190s、0.487s 和 0.396s；2-OHPhe 每增加 2.7 倍，PT 延长 0.047s；9-羟基菲（9-OHPhe）和 1-羟基芘（1-OHPyr）每增加 2.7 倍，TT 分别缩短 0.087s 和 0.031s；1-羟基萘（1-OHNap）每增加 2.7 倍，纤维蛋白原（FIB）升高 0.032g/L。还观察到 2-OHPhe 与 APTT 的非线性关联以及 1-OHNap 与 FIB 的非线性关联。此外，BKMR 和 Q-g 模型表明，PAHs 混合物与 APTT 和 TT 缩短有关。BKMR 还揭示了 2-OHPhe 与 PT 的非线性关联以及 2-OHPhe 和 3-OHPhe 对 APTT 的交互作用。我们的研究结果表明，尿中 PAHs 与凝血时间缩短和纤维蛋白原升高有关。因此，应对晚期孕妇给予更多关注，以预防与 PAHs 相关的血栓形成风险。未来需要进行前瞻性研究来证实我们的发现并探索潜在的生物学机制。
