免疫球蛋白 G4 相关疾病、淋巴结病和淋巴瘤：组织病理学特征和诊断方法。
Immunoglobulin G4-Related Disease, Lymphadenopathy, and Lymphoma: Histopathologic Features and Diagnostic Approach.
机构信息
Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Surg Pathol Clin. 2023 Jun;16(2):177-195. doi: 10.1016/j.path.2023.01.002. Epub 2023 Mar 27.
Lymphadenopathy occurring in patients with immunoglobulin G4 (IgG4)-related disease, termed IgG4-related lymphadenopathy, shows morphologic heterogeneity and overlap with other nonspecific causes of lymphadenopathy including infections, immune-related disorders, and neoplasms. This review describes the characteristic histopathologic features and diagnostic approach to IgG4-related disease and IgG4-related lymphadenopathy, with comparison to nonspecific causes of increased IgG4-positive plasma cells in lymph nodes, and with emphasis on distinction from IgG4-expressing lymphoproliferative disorders.
发生于 IgG4 相关疾病（IgG4-related disease）患者的淋巴结病，称为 IgG4 相关淋巴结病（IgG4-related lymphadenopathy），表现出形态学的异质性和与其他非特异性淋巴结病病因的重叠，包括感染、免疫相关性疾病和肿瘤。本综述描述了 IgG4 相关疾病和 IgG4 相关淋巴结病的特征性组织病理学特征和诊断方法，与非特异性淋巴结中 IgG4 阳性浆细胞增多的病因进行了比较，并强调了与 IgG4 表达的淋巴增生性疾病的鉴别。
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