Optimizing pulse sequences for magnetic resonance imaging of the musculoskeletal system.

On the surface, pulse sequence optimization seems like a difficult problem because of the many variables involved. In practice, however, the simple strategy of obtaining both T1- and T2-weighted images of the body part in question is adequate in most musculoskeletal imaging. This strategy virtually guarantees the production of images with adequate contrast between normal and abnormal tissue, no matter which of the common background tissues is considered. Although intravenous contrast agents can improve the already excellent contrast between musculoskeletal tissues, it is too early to tell the exact role they will play in the work-up of musculoskeletal disease.