The Texas Children's Hospital, Section of Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, TX, United States.
J Immunol Methods. 2023 Aug;519:113485. doi: 10.1016/j.jim.2023.113485. Epub 2023 May 5.
B cells are a key component of the humoral (antibody-mediated) immune response which is responsible for defense against a variety of pathogens. Here we provide an overview of the current understanding of B cell development and function and briefly describe inborn errors of immunity associated with B cell development defects which can manifest as immune deficiency, malignancy, autoimmunity, or allergy. The knowledge and application of B cell biology are essential for laboratory evaluation and clinical assessment of these B cell disorders.
B 细胞是体液（抗体介导）免疫应答的关键组成部分，负责抵御各种病原体。在这里，我们提供了对 B 细胞发育和功能的当前理解的概述，并简要描述了与 B 细胞发育缺陷相关的先天性免疫缺陷，这些缺陷可表现为免疫缺陷、恶性肿瘤、自身免疫或过敏。B 细胞生物学的知识和应用对于这些 B 细胞疾病的实验室评估和临床评估至关重要。
