Zhang Y F, Zhang H X, Yang J C, Qu Y M, Jiang Y, Li J L
Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2023 May 9;103(17):1340-1348. doi: 10.3760/cma.j.cn112137-20220819-01765.
To conduct a meta-analysis on the influencing factors of mild cognitive impairment (MCI) in the Chinese elderly. The literature related to the influencing factors of MCI in Chinese elderly population was retrieved through CNKI, Wanfang, VIP, PubMed, Embase and Web of Science databases up to March 13, 2022. Stata17.0 software was used to calculate the combined risk ratio ( with the 95% confidence interval (, test the heterogeneity, and assess the publication bias. A total of 2 450 articles were retrieved, and 49 articles met the inclusion criteria, including 5 cohort studies and 44 case-control studies. Meta-analysis results showed that male (=0.778, 95%: 0.696-0.870, =73.1), education>6years (=0.428, 95%: 0.374-0.490, =86.9) and regular exercise (=0.496, 95%: 0.421-0.585, =81.5) were protective factors for MCI, while age≥70 years (=2.431, 95%: 2.086-2.833, =79.3), family history of dementia (=3.228, 95%: 2.140-4.867, =0.0), smoking (=1.214, 95%: 1.098-1.342, =78.8), alcohol consumption (=1.165, 95%: 1.047-1.297, =68.2), solitary living (=2.816, 95%: 2.123-3.736, =42.0), insomnia (=1.402, 95%: 1.093-1.799, =41.3), overweight/obesity (=1.431, 95%: 1.207-1.696, =75.9), hypertension (=1.731, 95%: 1.589-1.886, =67.1), hyperlipidemia (=1.722, 95%: 1.541-1.924, =63.9), diabetes mellitus (=1.495, 95%: 1.341-1.666, =71.6), cardiovascular diseases (=1.671, 95%: 1.446-1.932, =74.6) and cerebrovascular diseases (=2.309, 95%: 2.040-2.613, =76.3) were risk factors of MCI. The present study indicates that male, junior high school education or above and regular exercise are protective factors of MCI, while age≥70 years, family history of dementia, smoking, alcohol consumption, living alone, insomnia, overweight/obesity, hypertension, hyperlipidemia, diabetes, cardiovascular diseases and cerebrovascular diseases are risk factors of MCI.
对中国老年人轻度认知障碍（MCI）的影响因素进行荟萃分析。通过中国知网、万方、维普、PubMed、Embase和Web of Science数据库检索截至2022年3月13日与中国老年人群MCI影响因素相关的文献。使用Stata17.0软件计算合并风险比（及其95%置信区间），检验异质性，并评估发表偏倚。共检索到2450篇文章，49篇符合纳入标准，包括5项队列研究和44项病例对照研究。荟萃分析结果显示，男性（=0.778，95%：0.696 - 0.870，=73.1）、受教育年限>6年（=0.428，95%：0.374 - 0.490，=86.9）和经常锻炼（=0.496，95%：0.421 - 0.585，=81.5）是MCI的保护因素，而年龄≥70岁（=2.431，95%：2.086 - 2.833，=79.3）、痴呆家族史（=3.228，95%：2.140 - 4.867，=0.0）、吸烟（=1.214，95%：1.098 - 1.342，=78.8）、饮酒（=1.165，95%：1.047 - 1.297，=68.2）、独居（=2.816，95%：2.123 - 3.736，=42.0）、失眠（=1.402，95%：1.093 - 1.799，=41.3）、超重/肥胖（=1.431，95%：1.207 - 1.696，=75.9）、高血压（=1.731，95%：1.589 - 1.886，=67.1）、高脂血症（=1.722，95%：1.541 - 1.924，=63.9）、糖尿病（=1.495，95%：1.341 - 1.666，=71.6）、心血管疾病（=1.671，95%：1.446 - 1.932，=74.6）和脑血管疾病（=2.309，95%：2.040 - 2.613，=76.3）是MCI的危险因素。本研究表明，男性、初中及以上学历和经常锻炼是MCI的保护因素，而年龄≥70岁、痴呆家族史、吸烟、饮酒、独居、失眠、超重/肥胖、高血压、高脂血症、糖尿病、心血管疾病和脑血管疾病是MCI的危险因素。
