School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
International Education College, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Inflammopharmacology. 2023 Aug;31(4):1629-1645. doi: 10.1007/s10787-023-01196-y. Epub 2023 May 7.
Quercetin, a typical flavonoid derived from a common natural plant, has multiple biological activities. Previous research in animal models has demonstrated the effectiveness of quercetin in treating rheumatoid arthritis (RA). The pharmacological effects and probable mechanisms of quercetin were evaluated in this study. Three databases, PubMed, Web of Science, and Embase, were searched for relevant studies from the creation of the databases to November 2022. Methodological quality was assessed using the SYRCLE risk of bias tool. STATA 15.1 was used to perform the statistical analysis. This research included 17 studies involving 251 animals. The results indicated that quercetin was able to reduce arthritis scores, paw swelling, histopathological scores, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), malondialdehyde (MDA), reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), nuclear factor kappa B (NF-kB) and increase interleukin-10 (IL-10), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glutathione (GSH), and heme oxygenase-1 (HO-1). These may be related to quercetin's potential anti-inflammatory, anti-oxidative stress, and osteoprotective properties. However, more high-quality animal studies are needed to assess the effect of quercetin on RA. Additionally, the safety of quercetin requires further confirmation. Given the importance of the active ingredient, dose selection and the improvement of quercetin's bioavailability remain to be explored.
槲皮素是一种源自常见天然植物的典型类黄酮，具有多种生物学活性。之前的动物模型研究表明，槲皮素在治疗类风湿关节炎（RA）方面具有有效性。本研究评估了槲皮素的药理作用和可能的机制。从数据库创建到 2022 年 11 月，我们在 PubMed、Web of Science 和 Embase 这三个数据库中搜索了相关研究。使用 SYRCLE 偏倚风险工具评估方法学质量。使用 STATA 15.1 进行统计分析。这项研究包括 17 项涉及 251 只动物的研究。结果表明，槲皮素能够降低关节炎评分、足肿胀、组织病理学评分、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白-1（MCP-1）、C 反应蛋白（CRP）、丙二醛（MDA）、活性氧（ROS）、硫代巴比妥酸反应物质（TBARS）、核因子 kappa B（NF-kB）和增加白细胞介素-10（IL-10）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）和血红素加氧酶-1（HO-1）。这些可能与槲皮素的潜在抗炎、抗氧化应激和护骨作用有关。然而，需要更多高质量的动物研究来评估槲皮素对 RA 的影响。此外，槲皮素的安全性需要进一步确认。鉴于活性成分的重要性，剂量选择和提高槲皮素的生物利用度仍有待探索。
