Nagarajan Ashok Kumar, Manoharan Krishnaswamy, Moozhiyil Shreya
Department of DVL, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India.
Indian J Dermatol. 2023 Jan-Feb;68(1):123. doi: 10.4103/ijd.ijd_1038_20.
Collagenomas are connective tissue nevi characterized by an imbalance in the distribution and amount of collagen in the extracellular matrix. Shagreen patch, a collagenoma of tuberous sclerosis, is a classical finding in this genodermatosis (Tuberous Sclerosis). Though the prototypical lesion is a shagreen patch, some individuals manifest only small collagenomas, and these can hinder a diagnosis of tuberous sclerosis and thus mask underlying systemic involvement as was seen in this case we have reported, wherein a 22-year-old male presented with segmental collagenomas over the face and calcified subependymal nodules of the brain on further investigation.
胶原瘤是一种结缔组织痣，其特征是细胞外基质中胶原蛋白的分布和数量失衡。鲨鱼皮斑，即结节性硬化症的一种胶原瘤，是这种遗传性皮肤病（结节性硬化症）的典型表现。尽管典型病变是鲨鱼皮斑，但有些个体仅表现为小的胶原瘤，这些小胶原瘤可能会妨碍结节性硬化症的诊断，从而掩盖潜在的全身受累情况，就像我们报道的这个病例一样，一名22岁男性面部出现节段性胶原瘤，进一步检查发现脑部有钙化的室管膜下结节。
