Peng Anjiao, Lai Wanlin, Liu Zhu, Wang Mingda, Chen Shujuan, Zhao Xia, Zhu Yuanfeng, Chen Lei
Department of Neurology, Joint Research Institute of Altitude Health, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Hum Neurosci. 2023 Apr 20;17:1143690. doi: 10.3389/fnhum.2023.1143690. eCollection 2023.
Antisaccade is closely associated with cognitive ability in Alzheimer's disease (AD). However, studies regarding antisaccade in the early stages of AD are scarce. Considering that first-degree family history is a well-established risk factor for AD, we explored the influence of family history on the performance of antisaccade tasks in individuals with normal cognition.
In total, 44 participants (aged 50-66 years) with a family history of AD (FH+) and 44 age-, gender-, and educational level-matched controls (FH-) were enrolled in our study. After cognitive assessment using the Montreal Cognitive Assessment and Mini-mental State Examination, participants underwent antisaccade trials, and all parameters were recorded using an eye tracker.
While the average velocity was relatively lower in FH+ individuals than in FH- individuals (107.9 ± 14.3°/s vs. 132.9 ± 23.7°/s, < 0.001), FH+ individuals surprisingly showed relatively fewer uninhibited reflexive saccades (44.7 ± 26.0% vs. 56.2 ± 24.7%, = 0.037) than the control group. They also required a relatively shorter time to detect and correct false saccades (121.6 ± 40.7 ms vs. 143.9 ± 37.0 ms, = 0.023).
This study showed that family history is associated with alterations in antisaccadic parameters, suggesting that eye tracking can be used to assess oculomotor control and executive function in individuals at risk of developing dementia.
反扫视与阿尔茨海默病（AD）的认知能力密切相关。然而，关于AD早期阶段反扫视的研究较少。鉴于一级家族史是AD公认的危险因素，我们探讨了家族史对认知正常个体反扫视任务表现的影响。
本研究共纳入44名有AD家族史（FH+）的参与者（年龄50 - 66岁）和44名年龄、性别及教育水平相匹配的对照组（FH-）。在使用蒙特利尔认知评估量表和简易精神状态检查表进行认知评估后，参与者进行反扫视试验，并使用眼动仪记录所有参数。
虽然FH+个体的平均速度相对低于FH-个体（107.9±14.3°/秒对132.9±23.7°/秒，<0.001），但令人惊讶的是，FH+个体出现的不受抑制的反射性扫视相对较少（44.7±26.0%对56.2±24.7%，=0.037）。他们检测和纠正错误扫视所需的时间也相对较短（121.6±40.7毫秒对143.9±37.0毫秒，=0.023）。
本研究表明家族史与反扫视参数的改变有关，提示眼动追踪可用于评估有患痴呆症风险个体的眼球运动控制和执行功能。
