Kameyama T, Nabeshima T, Matsuno K
Res Commun Chem Pathol Pharmacol. 1986 May;52(2):225-35.
The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1, 3-benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The alpha 2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an alpha 2-adrenoreceptor, but not an endogenous opioid system.
将替扎尼定[5-氯-4-(2-咪唑啉-2-基氨基)-2,1,3-苯并噻二唑]与可乐定相比，研究了其对小鼠核心体温的影响。替扎尼定可降低未麻醉、自由活动的正常小鼠的核心体温。可乐定可使正常小鼠体温过低。α2拮抗剂育亨宾可拮抗替扎尼定和可乐定诱导的体温过低，而纳洛酮未能拮抗体温过低。结论是，替扎尼定和可乐定通过α2肾上腺素能受体产生相似的体温过低效应，但不是通过内源性阿片系统。
